Reaction Details Report a problem with these data
Target
Farnesyl pyrophosphate synthase
Ligand
BDBM12577
Substrate
n/a
Meas. Tech.
ChEMBL_69350 (CHEMBL677586)
IC50
20±n/a nM
Citation
 Szabo, CM; Matsumura, Y; Fukura, S; Martin, MB; Sanders, JM; Sengupta, S; Cieslak, JA; Loftus, TC; Lea, CR; Lee, HJ; Koohang, A; Coates, RM; Sagami, H; Oldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem 45:2185-96 (2002) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM12577
Synonyms:
Bisphosphonate 2 | CHEMBL997 | JMC515594 Compound 53 | {1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C9H23NO7P2
Mol. Mass.:
319.2289
SMILES:
CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O
Structure:
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