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Found 210 with Last Name = 'cleasby' and Initial = 'a'
LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/mole IC50:  59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25980(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Affinity DataKi:  240nM ΔG°:  -37.4kJ/mole IC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi:  400nM ΔG°:  -36.2kJ/mole IC50:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25981(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Affinity DataKi:  480nM ΔG°:  -35.7kJ/mole IC50:  3.00E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25979(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Affinity DataKi:  1.60E+3nM ΔG°:  -32.7kJ/mole IC50:  1.00E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25979(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.4kJ/mole IC50:  8.40E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25981(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25980(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25979(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25980(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Affinity DataKi: >5.40E+3nM ΔG°: >-29.8kJ/mole IC50: >1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25981(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Affinity DataKi: >5.40E+3nM ΔG°: >-29.8kJ/mole IC50: >1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4942((2R,3R,4S)-4-carbamimidamido-2-(diethylcarbamoyl)-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4940((2R,3R,4S)-4-carbamimidamido-2-(dipropylcarbamoyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4945((2R,3R,4S)-4-amino-3-acetamido-2-[(2-phenylethyl)(...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4967((2R,3R,4S)-4-amino-3-acetamido-2-{[2-(4-phenylphen...)
Affinity DataIC50:  3nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4937((2R,3R,4S)-4-amino-2-(diethylcarbamoyl)-3-acetamid...)
Affinity DataIC50:  3nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4941((2R,3R,4S)-4-amino-3-acetamido-2-[ethyl(propyl)car...)
Affinity DataIC50:  3nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4929((2R,3R,4S)-4-amino-2-(dipropylcarbamoyl)-3-acetami...)
Affinity DataIC50:  3nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112617(CHEMBL3608786)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza B virus (B/Lee/40))
TBA

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of influenza B sialidase (neuraminidase)More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4943((2R,3R,4S)-4-amino-2-[butyl(propyl)carbamoyl]-3-ac...)
Affinity DataIC50:  4nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4933((2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[methyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuraminidase(Influenza B virus (B/Lee/40))
TBA

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  4nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type BMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112628(CHEMBL3608789)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM50288444((4S,5R,6R)-5-Acetylamino-4-guanidino-6-(phenethyl-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4952((2R,3R,4S)-4-amino-3-acetamido-2-[ethyl(2-phenylet...)
Affinity DataIC50:  5nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4952((2R,3R,4S)-4-amino-3-acetamido-2-[ethyl(2-phenylet...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4945((2R,3R,4S)-4-amino-3-acetamido-2-[(2-phenylethyl)(...)
Affinity DataIC50:  5nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112631(CHEMBL3608790)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112618(CHEMBL3608787)
Affinity DataIC50:  6nMAssay Description:Inhibition of DDR1 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112634(CHEMBL3608791)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112618(CHEMBL3608787)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112615(CHEMBL3608785)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526494(CHEMBL4439454)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526495(CHEMBL4452633)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112615(CHEMBL3608785)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of c-Kit (unknown origin) using biotinylated HER2 peptide as substrate by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526492(CHEMBL4454901)
Affinity DataIC50:  14nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4958((2R,3R,4S)-4-amino-3-acetamido-2-[(2-methylpropyl)...)
Affinity DataIC50:  14nMAssay Description:Compound was tested for inhibitory concentration against Influenza sialidase type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526486(CHEMBL4526974)
Affinity DataIC50:  15nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM50288445((4S,5R,6R)-5-Acetylamino-6-dibutylcarbamoyl-4-guan...)
Affinity DataIC50:  16nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526498(CHEMBL4530713)
Affinity DataIC50:  16nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526514(CHEMBL4443093)
Affinity DataIC50:  17nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112617(CHEMBL3608786)
Affinity DataIC50:  19nMAssay Description:Inhibition of c-Kit (unknown origin) using biotinylated HER2 peptide as substrate by time resolved fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526487(CHEMBL4458862)
Affinity DataIC50:  20nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
TBA

Curated by ChEMBL
LigandPNGBDBM4948((2R,3R,4S)-4-amino-3-acetamido-2-[nonyl(propyl)car...)
Affinity DataIC50:  23nMAssay Description:Inhibition of influenza A sialidase (neuraminidase)More data for this Ligand-Target Pair
In DepthDetails Article
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