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Found 129 with Last Name = 'mahmood' and Initial = 'a'
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50058293(3-(4-Fluoro-phenyl)-8-(3-phenyl-propyl)-8-aza-bicy...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50058287(3-(4-Fluoro-phenyl)-8-(5-phenyl-pentyl)-8-aza-bicy...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50058286((1R,12R) | (1R,12S) | CHEMBL119561 | Diastereiosom...)
Affinity DataIC50:  7.38nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50412149(CHEMBL497967)
Affinity DataIC50:  10nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50386566(CHEMBL2048438)
Affinity DataIC50:  13nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598327(CHEMBL5178892)
Affinity DataIC50:  18nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50058294((2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-(3-phe...)
Affinity DataIC50:  19.7nMAssay Description:Inhibition of [3H]- citalopram binding to serotonin transporter of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50058294((2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-(3-phe...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598327(CHEMBL5178892)
Affinity DataIC50:  30nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells assessed as reduction in BzATP-induced activity incubated for 5 to 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598318(CHEMBL5205239)
Affinity DataIC50:  34nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598318(CHEMBL5205239)
Affinity DataIC50:  34nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells assessed as reduction in BzATP-induced activity incubated for 5 to 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50058292(CHEMBL118075 | O-1196 | O-863 | [N-[2-[(3'-N'-Prop...)
Affinity DataIC50:  37.2nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598326(CHEMBL5206892)
Affinity DataIC50:  39nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596624(CHEMBL5204261)
Affinity DataIC50:  40nMAssay Description:Negative allosteric modulation activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598320(CHEMBL5174305)
Affinity DataIC50:  45nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598320(CHEMBL5174305)
Affinity DataIC50:  47nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells assessed as reduction in BzATP-induced activity incubated for 5 to 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50058287(3-(4-Fluoro-phenyl)-8-(5-phenyl-pentyl)-8-aza-bicy...)
Affinity DataIC50:  49.9nMAssay Description:Inhibition of [3H]- citalopram binding to serotonin transporter of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598322(CHEMBL5200114)
Affinity DataIC50:  55nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50058295(8-Benzyl-3-(4-fluoro-phenyl)-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50:  58.9nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596640(CHEMBL5194775)
Affinity DataIC50:  68nMAssay Description:Negative allosteric modulation activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in ethidium bromide dye uptake p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596640(CHEMBL5194775)
Affinity DataIC50:  73nMAssay Description:Negative allosteric modulation activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596637(CHEMBL5188202)
Affinity DataIC50:  99nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50058289((2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-(5-phe...)
Affinity DataIC50:  99nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598319(CHEMBL5194724)
Affinity DataIC50:  110nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50058286((1R,12R) | (1R,12S) | CHEMBL119561 | Diastereiosom...)
Affinity DataIC50:  124nMAssay Description:Inhibition of [3H]- citalopram binding to serotonin transporter of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50058293(3-(4-Fluoro-phenyl)-8-(3-phenyl-propyl)-8-aza-bicy...)
Affinity DataIC50:  133nMAssay Description:Inhibition of [3H]- citalopram binding to serotonin transporter of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596637(CHEMBL5188202)
Affinity DataIC50:  155nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in ethidium bromide dye uptake preincubated for 15 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598319(CHEMBL5194724)
Affinity DataIC50:  173nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells assessed as reduction in BzATP-induced activity incubated for 5 to 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50506158(CHEMBL4521594)
Affinity DataIC50:  211nMAssay Description:Antagonist activity at human P2X4 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50058290((2R,3S)-8-Benzyl-3-[bis-(4-fluoro-phenyl)-methoxy]...)
Affinity DataIC50:  223nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598316(CHEMBL5184613)
Affinity DataIC50:  247nMAssay Description:Antagonist activity against human P2X2R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50058292(CHEMBL118075 | O-1196 | O-863 | [N-[2-[(3'-N'-Prop...)
Affinity DataIC50:  264nMAssay Description:Inhibition of [3H]- citalopram binding to serotonin transporter of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50279764(CHEMBL55730 | Diastereiosomer of[N-[2-[(3'-N'-Prop...)
Affinity DataIC50:  343nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50279764(CHEMBL55730 | Diastereiosomer of[N-[2-[(3'-N'-Prop...)
Affinity DataIC50:  343nMAssay Description:Inhibition of [3H]WIN35,428 binding to dopamine transporter using of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50058289((2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-(5-phe...)
Affinity DataIC50:  550nMAssay Description:Inhibition of [3H]- citalopram binding to serotonin transporter of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598317(CHEMBL5208562)
Affinity DataIC50:  634nMAssay Description:Antagonist activity against human P2X2R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596635(CHEMBL5184546)
Affinity DataIC50:  699nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596629(CHEMBL5200337)
Affinity DataIC50:  732nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596635(CHEMBL5184546)
Affinity DataIC50:  796nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in ethidium bromide dye uptake preincubated for 15 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596632(CHEMBL5187239)
Affinity DataIC50:  890nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598315(CHEMBL5186938)
Affinity DataIC50:  902nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50:  904nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598327(CHEMBL5178892)
Affinity DataIC50:  908nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598318(CHEMBL5205239)
Affinity DataIC50:  935nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598320(CHEMBL5174305)
Affinity DataIC50:  1.05E+3nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596625(CHEMBL5174645)
Affinity DataIC50:  1.06E+3nMAssay Description:Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50058295(8-Benzyl-3-(4-fluoro-phenyl)-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of [3H]- citalopram binding to serotonin transporter of Cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50596633(CHEMBL5174595)
Affinity DataIC50:  1.08E+3nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598315(CHEMBL5186938)
Affinity DataIC50:  1.11E+3nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells assessed as reduction in BzATP-induced activity incubated for 5 to 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50598321(CHEMBL5172890)
Affinity DataIC50:  1.25E+3nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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