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Found 700 with Last Name = 'patterson' and Initial = 'av'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) incubated for 90 mins in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM431867(US10550114, Compound 1a)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of 6xHis-tagged full-length wild-type AKT1 (unknown origin) expressed in baculovirus infected Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 90 mins in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260190(CHEMBL4100258)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown orgin) (445 to 753 residues) expressed in Rosetta (NEB) cells using poly(Glu, Tyr) 4:1 peptide as...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260193(CHEMBL4092354)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260185(CHEMBL4096041)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260181(CHEMBL4077029)
Affinity DataIC50:  0.910nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260182(CHEMBL4092508)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260185(CHEMBL4096041)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260188(CHEMBL4069509)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260192(CHEMBL4088313)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260191(CHEMBL4103795)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260187(CHEMBL4096738)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260184(CHEMBL4068733)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50525939(Balversa | Erdafitinib | Jnj-42756493)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 amino acids) incubated for 60 mins by time-resolved fluorescence kinase assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260190(CHEMBL4100258)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50: <1.20nMAssay Description:Inhibition of human FGFR4 using Poly [E,Y] 4:1 substrate pre-incubated for 15 to 60 mins followed by ATP and [gamma33P]-ATP additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50: <1.20nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260183(CHEMBL4079538)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260186(CHEMBL4060079)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50604180(CHEMBL5169893)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown orgin) (445 to 753 residues) expressed in Rosetta (NEB) cells using poly(Glu, Tyr) 4:1 peptide as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260192(CHEMBL4088313)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260182(CHEMBL4092508)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260184(CHEMBL4068733)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607474(CHEMBL5220871)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260193(CHEMBL4092354)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260191(CHEMBL4103795)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260207(CHEMBL4102560)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260199(CHEMBL4066038)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260183(CHEMBL4079538)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US11136320, Reference Compound | US9266883, 83)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human FGFR4 (447 to 753 residues) incubated for 30 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607473(CHEMBL5218602)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260197(CHEMBL4072483)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human FGFR1 using poly[Glu:Tyr] (4:1) substrate and ATP and [gamma33P]-ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human FGFR2 using poly[Glu:Tyr] (4:1) substrate and ATP and [gamma33P]-ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM333185(US10196436, Compound 35)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown orgin) (445 to 753 residues) expressed in Rosetta (NEB) cells using poly(Glu, Tyr) 4:1 peptide as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of His-tagged cytoplasmic recombinant human FGFR2 (403 to 822 residues) expressed in baculovirus expression system using Tyr 4 peptide as ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260198(CHEMBL4099403)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260205(CHEMBL4061908)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260186(CHEMBL4060079)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607471(CHEMBL5218768)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50525939(Balversa | Erdafitinib | Jnj-42756493)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human FGFR2 incubated for 30 mins by time-resolved fluorescence kinase assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM209325(US11136320, Reference Compound | US9266883, 83)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin) expressed in Escherichia coli Rosetta2 (DE3) (NEB) cells in presence of ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of FGFR2 (unknown origin) using poly[Glu:Tyr] (4:1) substrate and ATP and [gamma33P]-ATP incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50233462(CHEMBL4065231)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of His-tagged cytoplasmic recombinant human FGFR4 (781 to 1338 residues) expressed in baculovirus expression system using Tyr 4 peptide as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50260188(CHEMBL4069509)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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