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Found 592 with Last Name = 'raju' and Initial = 'b'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058126(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Affinity DataKi:  0.430nMAssay Description:Binding affinity against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50447056(CHEMBL1378094 | US9320722, CB7 | US9328112, CB7)
Affinity DataKi:  82nMAssay Description:Competitive inhibition of human ALDH3A1 using benzaldehyde as substrate by Lineweaver-Burk plot analysis in presence of 1.5 mM NADP+More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50447056(CHEMBL1378094 | US9320722, CB7 | US9328112, CB7)
Affinity DataKi:  110nMAssay Description:Non-competitive inhibition of human ALDH3A1 using benzaldehyde as substrate by Lineweaver-Burk plot analysis in presence of 100 to 500 uM NADP+More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50447056(CHEMBL1378094 | US9320722, CB7 | US9328112, CB7)
Affinity DataKi:  200nMAssay Description:Inhibition of human wild-type ALDH3A1-mediated benzaldehyde oxidationMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50448790(CHEMBL3128208)
Affinity DataKi:  290nMAssay Description:Noncompetitive/mixed type inhibition of human ALDH1A1 by Lineweaver-Burk plot analysis in presence of NAD+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50448790(CHEMBL3128208)
Affinity DataKi:  380nMAssay Description:Inhibition of human ALDH3A1 using benzaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50448790(CHEMBL3128208)
Affinity DataKi:  500nMAssay Description:Inhibition of human ALDH3A1 by Lineweaver-Burk plot analysis in presence of NADP+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50448790(CHEMBL3128208)
Affinity DataKi:  900nMAssay Description:Competitive inhibition of human ALDH1A1 using propionaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50448790(CHEMBL3128208)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human ALDH2 using propionaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human ALDH3A1 using benzaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50448790(CHEMBL3128208)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of human ALDH2 by Lineweaver-Burk plot analysis in presence of NAD+More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human ALDH3A1 by Lineweaver-Burk plot analysis in presence of NADP+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM109210(CB29)
Affinity DataKi:  4.70E+3nM IC50:  1.60E+4nMAssay Description:To determine the IC50 values for CB29 and its analogues, propionaldehyde was used as the substrate for ALDH1A1 and ALDH2 and benzaldehyde was used as...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  1.50E+4nMAssay Description:Competitive inhibition of human ALDH2 using propionaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  3.40E+4nMAssay Description:Noncompetitive/mixed type inhibition of human ALDH2 by Lineweaver-Burk plot analysis in presence of NAD+More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50098772(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of I-ET-1 binding to human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058138(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Affinity DataIC50:  0.630nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058143(2-[2-(2,4-Dimethyl-phenyl)-acetyl]-thiophene-3-sul...)
Affinity DataIC50:  0.760nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058144(2-[2-(2,4-Dimethyl-phenyl)-acetyl]-thiophene-3-sul...)
Affinity DataIC50:  0.970nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288051(5-Dimethylamino-naphthalene-1-sulfonic acid (4-bro...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058133(2-[2-(6-Cyano-benzo[1,3]dioxol-5-yl)-acetyl]-thiop...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288038(Biphenyl-2-sulfonic acid (4-bromo-3-methyl-isoxazo...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058126(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058111(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  2.60nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058111(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  2.60nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058141(2-[2-(2,4-Dimethyl-phenyl)-acetyl]-thiophene-3-sul...)
Affinity DataIC50:  2.70nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288013(5-Bromo-N-(4-bromo-3-methyl-isoxazol-5-yl)-2-ethyl...)
Affinity DataIC50:  2.80nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058134(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058080(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058132(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Affinity DataIC50:  3.30nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058146(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.40nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058106(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.40nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058114(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.80nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288040(Biphenyl-2-sulfonic acid (4-chloro-3-methyl-isoxaz...)
Affinity DataIC50:  3.80nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058120(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.90nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058105(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.90nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058099(Acetic acid 2-(6-{[3-(4-chloro-3-methyl-isoxazol-5...)
Affinity DataIC50:  4.5nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058117(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  5.10nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058097(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  5.60nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50034435(5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...)
Affinity DataIC50:  5.80nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058103(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058075(Acetic acid 2-(6-{[3-(4-chloro-3-methyl-isoxazol-5...)
Affinity DataIC50:  6.10nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288007(CHEMBL311138 | N-(4-Bromo-3-methyl-isoxazol-5-yl)-...)
Affinity DataIC50:  6.20nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058084(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  6.60nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058092(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  6.80nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058124(2-[2-(2,5-Dimethyl-phenyl)-acetyl]-thiophene-3-sul...)
Affinity DataIC50:  7.20nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288045(CHEMBL78563 | N-(4-Bromo-3-methyl-isoxazol-5-yl)-5...)
Affinity DataIC50:  8.10nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50289940(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  8.30nMAssay Description:In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50068700(Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataIC50:  8.30nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50289945(3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thioph...)
Affinity DataIC50:  8.90nMAssay Description:In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorMore data for this Ligand-Target Pair
In DepthDetails Article
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