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Found 102 with Last Name = 'mcclure' and Initial = 'de'
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016400(2,6-Dimethyl-4-(2-methylsulfanyl-3-nitro-phenyl)-1...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452435(CHEMBL2110302)
Affinity DataKi:  30nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016398(2,6-Dimethyl-4-(2-methylsulfanyl-5-nitro-phenyl)-1...)
Affinity DataKi:  80nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452433(CHEMBL2110168)
Affinity DataKi:  250nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452434(CHEMBL2110303)
Affinity DataKi:  500nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452432(CHEMBL2110169)
Affinity DataKi:  650nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452430(CHEMBL2110298)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452429(CHEMBL2110170)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452431(CHEMBL2110167)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452436(CHEMBL2110301)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  1.10nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225247(CHEMBL44558)
Affinity DataIC50:  2nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224790(CHEMBL333794)
Affinity DataIC50:  2nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224791(CHEMBL333795 | RU-29717)
Affinity DataIC50:  2.20nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM25764(ALPRENOLOL,(+) | ALPRENOLOL,(-) | Alfeprol | Alphe...)
Affinity DataIC50:  3nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50017543((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)
Affinity DataIC50:  3.10nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50017543((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)
Affinity DataIC50:  3.10nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225241(CHEMBL42242)
Affinity DataIC50:  3.30nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM25764(ALPRENOLOL,(+) | ALPRENOLOL,(-) | Alfeprol | Alphe...)
Affinity DataIC50:  4.90nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50225247(CHEMBL44558)
Affinity DataIC50:  7nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224790(CHEMBL333794)
Affinity DataIC50:  7nMAssay Description:In vitro affinity for alpha adrenergic receptor by displacement of 3[H]clonidine in calf cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225248(CHEMBL42309)
Affinity DataIC50:  14nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225234(CHEMBL41980)
Affinity DataIC50:  14nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50026852(1-Isopropylamino-3-(7-methyl-indan-4-yloxy)-propan...)
Affinity DataIC50:  18nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225235(CHEMBL42909)
Affinity DataIC50:  19nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225240(CHEMBL44501)
Affinity DataIC50:  19.6nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225240(CHEMBL44501)
Affinity DataIC50:  20nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50367112(CHEMBL1788270)
Affinity DataIC50:  20nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224792(CHEMBL332546)
Affinity DataIC50:  23nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50026853(CHEMBL368457 | Fluoren-9-one O-(3-tert-butylamino-...)
Affinity DataIC50:  25nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224793(CHEMBL330997)
Affinity DataIC50:  27nMAssay Description:In vitro affinity for alpha adrenergic receptor by displacement of 3[H]clonidine in calf cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM81993(BROMOCRIPTINE | Bromocriptine+ (GTP+) | Bromocript...)
Affinity DataIC50:  28nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM81993(BROMOCRIPTINE | Bromocriptine+ (GTP+) | Bromocript...)
Affinity DataIC50:  28nMAssay Description:Dopaminergic activity assessed in vitro for displacement of [3H]apomorphine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
LigandPNGBDBM50225241(CHEMBL42242)
Affinity DataIC50:  29nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367111(CHEMBL305153)
Affinity DataIC50:  29nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224793(CHEMBL330997)
Affinity DataIC50:  29nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50367111(CHEMBL305153)
Affinity DataIC50:  31nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224791(CHEMBL333795 | RU-29717)
Affinity DataIC50:  31nMAssay Description:In vitro affinity for alpha adrenergic receptor by displacement of 3[H]clonidine in calf cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224795(CHEMBL332337)
Affinity DataIC50:  33nMAssay Description:In vitro affinity for dopamine receptor by displacement of [3H]- apomorphine in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224790(CHEMBL333794)
Affinity DataIC50:  34nMAssay Description:In vitro affinity for alpha adrenergic receptor by displacement of 3[H]clonidine in calf cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405521(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Affinity DataIC50:  37nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026853(CHEMBL368457 | Fluoren-9-one O-(3-tert-butylamino-...)
Affinity DataIC50:  38nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225248(CHEMBL42309)
Affinity DataIC50:  39nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017543((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)
Affinity DataIC50:  41nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017543((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)
Affinity DataIC50:  41nMAssay Description:In vitro affinity for alpha adrenergic receptor by displacement of 3[H]clonidine in calf cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367112(CHEMBL1788270)
Affinity DataIC50:  43nMAssay Description:Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-1 adrenergic receptor in dog heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50224795(CHEMBL332337)
Affinity DataIC50:  46nMAssay Description:In vitro affinity for alpha adrenergic receptor by displacement of 3[H]clonidine in calf cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225250(CHEMBL42237)
Affinity DataIC50:  51nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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