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Found 106 with Last Name = 'crawford' and Initial = 'dt'
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.354nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181274(5-(3-((S)-2-((R)-4-(3-chlorophenyl)-3-hydroxybutyl...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471710(CHEMBL317748)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471711(CHEMBL98892)
Affinity DataIC50:  11nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20606((5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phe...)
Affinity DataIC50:  11nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20606((5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phe...)
Affinity DataIC50:  11nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181289(5-(3-((S)-2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-...)
Affinity DataIC50:  17nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50142488(7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  21nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181296(5-(3-((S)-2-(3-hydroxy-4-phenylbutyl)-5-oxopyrroli...)
Affinity DataIC50:  21nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181279(7-(2-(4-(3-chlorophenyl)-3-hydroxybutyl)-5-oxopyrr...)
Affinity DataIC50:  22nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | CHEMBL541649 | D3RKN_6 | N-methyl-N...)
Affinity DataIC50:  31nMAssay Description:Inhibition of recombinant PYK2More data for this Ligand-Target Pair
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50065941(1-{2-[4-(6-Methoxy-2-phenyl-3,4-dihydro-naphthalen...)
Affinity DataIC50:  41nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181277(4-(3-(2-(4-(3-chlorophenyl)-3-hydroxybutyl)-5-oxop...)
Affinity DataIC50:  42nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181291(4-{3-[2-(4-biphenyl-3-yl-3-hydroxy-butyl)-5-oxo-py...)
Affinity DataIC50:  47nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471707(CHEMBL98116)
Affinity DataIC50:  47nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181290(5-{3-[(S)-2-(4-biphenyl-3-yl-3-hydroxy-butyl)-5-ox...)
Affinity DataIC50:  50nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181284(7-((S)-2-(3-hydroxy-4-phenylbutyl)-5-oxopyrrolidin...)
Affinity DataIC50:  54nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181271(7-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethoxy)phe...)
Affinity DataIC50:  59nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181293(7-((S)-2-((R)-3-hydroxy-4-(3-(methoxymethyl)phenyl...)
Affinity DataIC50:  62nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181295(5-(3-((S)-2-(3-hydroxy-4-(naphthalen-2-yl)butyl)-5...)
Affinity DataIC50:  65nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181272(4-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50:  70nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181286(5-(3-((S)-2-((R)-4-(4-fluorophenyl)-3-hydroxybutyl...)
Affinity DataIC50:  70nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181282(5-(3-((S)-2-(4-(4-chlorophenyl)-3-hydroxybutyl)-5-...)
Affinity DataIC50:  80nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181282(5-(3-((S)-2-(4-(4-chlorophenyl)-3-hydroxybutyl)-5-...)
Affinity DataIC50:  86nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181294(5-{3-[(S)-2-(4-biphenyl-2-yl-3-hydroxy-butyl)-5-ox...)
Affinity DataIC50:  125nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181281(4-(3-(2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-oxop...)
Affinity DataIC50:  126nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471709(CHEMBL421389)
Affinity DataIC50:  132nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181290(5-{3-[(S)-2-(4-biphenyl-3-yl-3-hydroxy-butyl)-5-ox...)
Affinity DataIC50:  135nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181280(5-(3-((S)-2-(4-(4-ethylphenyl)-3-hydroxybutyl)-5-o...)
Affinity DataIC50:  140nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181274(5-(3-((S)-2-((R)-4-(3-chlorophenyl)-3-hydroxybutyl...)
Affinity DataIC50:  188nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181278(7-((S)-2-((R)-3-hydroxy-4-(3-(2-methoxyethyl)pheny...)
Affinity DataIC50:  210nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181285(4-(3-(2-(3-hydroxy-4-(3-phenoxyphenyl)butyl)-5-oxo...)
Affinity DataIC50:  220nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181283(4-(3-(2-(3-hydroxy-4-phenylbutyl)-5-oxopyrrolidin-...)
Affinity DataIC50:  250nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50471708(CHEMBL100303)
Affinity DataIC50:  270nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181273(7-[(S)-2-((R)-4-biphenyl-3-yl-3-hydroxy-butyl)-5-o...)
Affinity DataIC50:  337nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181275(7-((S)-2-((R)-4-(3-cyanophenyl)-3-hydroxybutyl)-5-...)
Affinity DataIC50:  388nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50:  483nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181276(7-((S)-2-(3-hydroxy-4-(3-phenoxyphenyl)butyl)-5-ox...)
Affinity DataIC50:  536nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181289(5-(3-((S)-2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-...)
Affinity DataIC50:  640nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181296(5-(3-((S)-2-(3-hydroxy-4-phenylbutyl)-5-oxopyrroli...)
Affinity DataIC50:  690nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181280(5-(3-((S)-2-(4-(4-ethylphenyl)-3-hydroxybutyl)-5-o...)
Affinity DataIC50:  1.20E+3nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181287(7-((S)-2-((R)-3-hydroxy-4-(3-hydroxyphenyl)butyl)-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181286(5-(3-((S)-2-((R)-4-(4-fluorophenyl)-3-hydroxybutyl...)
Affinity DataIC50:  1.21E+3nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181294(5-{3-[(S)-2-(4-biphenyl-2-yl-3-hydroxy-butyl)-5-ox...)
Affinity DataIC50:  1.60E+3nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181293(7-((S)-2-((R)-3-hydroxy-4-(3-(methoxymethyl)phenyl...)
Affinity DataIC50: >2.00E+3nMAssay Description:Binding affinity to human EP3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50410856(CHEMBL2113220)
Affinity DataIC50:  2.71E+3nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181288(4-(3-(2-(4-(4-fluorophenyl)-3-hydroxybutyl)-5-oxop...)
Affinity DataIC50:  2.77E+3nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181276(7-((S)-2-(3-hydroxy-4-(3-phenoxyphenyl)butyl)-5-ox...)
Affinity DataIC50: >3.20E+3nMAssay Description:Binding affinity to rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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