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Found 6 Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM50181298'
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-PGE2 from human EP4 receptor transfected with HEK293 cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50:  2nMAssay Description:Agonist activity at human EP4 receptor expressed in CHO cells co-transfected with CRE-beta-lactamase reporter gene assessed as increase in intracellu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to rat EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataEC50:  0.5nMAssay Description:Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed