Compile Data Set for Download or QSAR
maximum 50k data
Found 341 with Last Name = 'poch' and Initial = 'g'
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataKi:  4.40nM ΔG°:  -47.7kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  40nM ΔG°:  -42.2kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataKi:  54.9nM ΔG°:  -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataKi:  74nM ΔG°:  -40.3kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  88nM ΔG°:  -39.9kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12073((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  700nM ΔG°:  -35.1kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28763((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  971nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28763((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  971nM ΔG°:  -34.0kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12073((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.8kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  3nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  4nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM8485((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)
Affinity DataIC50:  4nMpH: 6.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180564(4-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmeth...)
Affinity DataIC50:  6.80nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM27878(13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...)
Affinity DataIC50:  7.40nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataIC50:  7.70nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12076((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  8nMpH: 6.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180558(4-(4-bromo-2-fluorophenylamino)-5-fluoro-N-(2-hydr...)
Affinity DataIC50:  9.30nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180572(4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180561(4-(4-bromo-2-fluorophenylamino)-5-fluoro-N-hydroxy...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180562(4-(4-bromo-2-fluorophenylamino)-N-(2-hydroxyethoxy...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM27878(13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...)
Affinity DataIC50: <25nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM27877(N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...)
Affinity DataIC50: <25nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180556(4-(4-bromo-2-fluorophenylamino)-N-(2-hydroxyethoxy...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180563(4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180573(4-(4-bromo-2-fluorophenylamino)-N-ethoxy-5-fluoro-...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180566(4-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmeth...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180571(4-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmeth...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180570(4-(4-bromo-2-fluorophenylamino)-5-fluoro-N-methoxy...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180560(4-(4-bromo-2-fluorophenylamino)-5-chloro-N-(2-hydr...)
Affinity DataIC50:  45nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM27877(N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...)
Affinity DataIC50:  57nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180569(4-(4-bromo-2-fluorophenylamino)-N-ethoxy-1,5-dimet...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataIC50:  88nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of NCoR incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM27877(N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...)
Affinity DataIC50: <100nMpH: 6.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180567(4-(4-bromo-2-fluorophenylamino)-N-methoxy-1,5-dime...)
Affinity DataIC50:  105nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180568(4-(4-bromo-2-fluorophenylamino)-5-fluoro-N,1-dimet...)
Affinity DataIC50:  118nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180574(4-(4-bromo-2-fluorophenylamino)-5-chloro-N-(cyclop...)
Affinity DataIC50:  124nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12077((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  450nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM12077((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)
Affinity DataIC50:  810nMpH: 6.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM50554669(CHEMBL4743677)
Affinity DataIC50:  956nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of NCoR incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180557(4-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmeth...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM50554669(CHEMBL4743677)
Affinity DataIC50:  2.25E+3nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStromelysin-1(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM27878(13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...)
Affinity DataIC50: >2.50E+3nMpH: 6.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Istituto Di Cristallografia

LigandPNGBDBM27877(N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...)
Affinity DataIC50: >2.50E+3nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50180565(4-(4-bromo-2-chlorophenylamino)-5,6-dichloro-N-(2-...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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