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Found 766 with Last Name = 'kumar' and Initial = 'j'
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315548(8-(2-Thioxo-7(3-m-iodophenyl)-2-(2-furyl)thiazolo[...)
Affinity DataKi:  0.00820nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type IV [15-340](Homo sapiens (Human))
B.R. Ambedkar Bihar University

LigandPNGBDBM223209(8-((6-Chloropyrimidin-4-yl)oxy)quinoline (Compound...)
Affinity DataKi:  0.0109nMAssay Description:The docking and scoring of ligands with CAMKIV protein was accomplished using ParDOCK module of Sanjeevini drug design suite, which is based on physi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315541(8-(2-Thioxo-7(3-allyl)-2-(2-furyl)thiazole[4,3-e]1...)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315544(8-(2-Thioxo-7(3-p-chlorophenyl.)-2-(2-furyl)thiazo...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315545(8-(2-Thioxo-7(3-m-chlorophenyl)-2-(2-furyl)thiazol...)
Affinity DataKi:  0.0380nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315538(8-(2-Thioxo-7(3-ethyl)-2-(2-furyl)thiazolo[4,3-e]1...)
Affinity DataKi:  0.0960nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315540(8-(2-Thioxo-7(3-butyl)-2-(2-furyl),thiazolo,[4,3-e...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM86757(CAS_0 | NSC_11603174 | [11C]MMP)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A/2C(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM50024605(CHEMBL3330603 | US9290463, E)
Affinity DataKi:  0.150nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:Preparation of Membrane Fractions from CHO-h5-HT1A Cells. Membranes from CHO cells stably expressing the human 5-HT1A receptor at a density of 8 pmol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315544(8-(2-Thioxo-7(3-p-chlorophenyl.)-2-(2-furyl)thiazo...)
Affinity DataKi:  0.152nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315545(8-(2-Thioxo-7(3-m-chlorophenyl)-2-(2-furyl)thiazol...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024574(CHEMBL3330616)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315539(8-(2-Thioxo-7(3-propyl)-2-(2-furyl)thiazolo[4,3-e]...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315546(8-(2-Thioxo-7(3-o-iodophenyl)-2-(2-furyl)thiazolo[...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024567(CHEMBL3330623)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024643(CHEMBL3329234)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315547(8-(2-Thioxo-7(3-p-iodophenyl)-2-(2-furyl)thiazolo[...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024647(CHEMBL3330599)
Affinity DataKi:  0.660nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315546(8-(2-Thioxo-7(3-o-iodophenyl)-2-(2-furyl)thiazolo[...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Columbia University Medical Center

Curated by ChEMBL
LigandPNGBDBM50419052(SB-399885)
Affinity DataKi:  0.776nMAssay Description:Displacement of [125I]SB-258585 from human recombinant 5HT6 receptor using methiothepin after 45 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024646(CHEMBL3330600)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024595(CHEMBL3330605)
Affinity DataKi:  0.835nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315542(8-(2-Thioxo-7(3-phenyl)-2-(2-furyl)thiazolo[4,3-e]...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392592(CHEMBL2153381)
Affinity DataKi:  1.10nMAssay Description:Inhibition of F10a assessed as S-2765 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50182020(2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-m...)
Affinity DataKi:  1.10nMAssay Description:Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024580(CHEMBL3330612)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024577(CHEMBL3330614)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50048466(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  1.23nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50180054(CHEMBL199824 | [O-methyl-11C]2-{4-[4-(7-methoxynap...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024573(CHEMBL3330617 | US9290463, A)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50392589(CHEMBL2153377)
Affinity DataKi:  1.5nMAssay Description:Inhibition of F10a assessed as S-2765 substrate hydrolysis by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50320446(CHEMBL1085510 | [N-methyl]5-methyl-3-[4-(3-phenyla...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]rauwolscine from adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024584(CHEMBL3330609)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024582(CHEMBL3330611)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315543(8-(2-Thioxo-7(3-p fluorophenyl)-2-(2-furyl)thiazol...)
Affinity DataKi:  2.02nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024566(CHEMBL3330624)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024605(CHEMBL3330603 | US9290463, E)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315548(8-(2-Thioxo-7(3-m-iodophenyl)-2-(2-furyl)thiazolo[...)
Affinity DataKi:  2.62nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024583(CHEMBL3330610)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315543(8-(2-Thioxo-7(3-p fluorophenyl)-2-(2-furyl)thiazol...)
Affinity DataKi:  3.21nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315538(8-(2-Thioxo-7(3-ethyl)-2-(2-furyl)thiazolo[4,3-e]1...)
Affinity DataKi:  3.56nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A/2C(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM50024573(CHEMBL3330617 | US9290463, A)
Affinity DataKi:  4nM ΔG°:  -44.6kJ/molepH: 7.4 T: 2°CAssay Description:Preparation of Membrane Fractions from CHO-h5-HT1A Cells. Membranes from CHO cells stably expressing the human 5-HT1A receptor at a density of 8 pmol...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50320446(CHEMBL1085510 | [N-methyl]5-methyl-3-[4-(3-phenyla...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]rauwolscine from adrenergic alpha2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50024587(CHEMBL3330606)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1AR (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College of Medicine

WIPO
LigandPNGBDBM581953(WO2023004291, Compound CDD-1819)
Affinity DataKi:  4.90nMAssay Description:To evaluate the potency of synthesized compounds against Mpro, the proteolytic activity of 50 nM Mpro -His and Mpro was first measured in the presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A/2C(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM210829(US9290463, B)
Affinity DataKi:  5.5nM ΔG°:  -43.8kJ/molepH: 7.4 T: 2°CAssay Description:Preparation of Membrane Fractions from CHO-h5-HT1A Cells. Membranes from CHO cells stably expressing the human 5-HT1A receptor at a density of 8 pmol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College of Medicine

WIPO
LigandPNGBDBM581952(WO2023004291, Compound CDD-1830)
Affinity DataKi:  5.60nMAssay Description:To evaluate the potency of synthesized compounds against Mpro, the proteolytic activity of 50 nM Mpro -His and Mpro was first measured in the presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A/2C(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM210830(US9290463, D)
Affinity DataKi:  6nM ΔG°:  -43.6kJ/molepH: 7.4 T: 2°CAssay Description:Preparation of Membrane Fractions from CHO-h5-HT1A Cells. Membranes from CHO cells stably expressing the human 5-HT1A receptor at a density of 8 pmol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50315547(8-(2-Thioxo-7(3-p-iodophenyl)-2-(2-furyl)thiazolo[...)
Affinity DataKi:  6.13nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 1(BOVINE)
Columbia University

Curated by PDSP Ki Database
LigandPNGBDBM86757(CAS_0 | NSC_11603174 | [11C]MMP)
Affinity DataKi:  6.75nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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