Found 105 with Last Name = 'nave' and Initial = 'j' TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 6.70nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 15nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 15nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM6B expressed in expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured a...More data for this Ligand-Target Pair
3D Structure (crystal)TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 37nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 39nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 46nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 61nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 89nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 140nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 390nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 820nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+3nMAssay Description:Affinity at P2X purinoceptor 1 (P2X1) and the value is expressed as IC50More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Affinity at P2X purinoceptor 3 (P2X3) and the value is expressed as IC50More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM4A expressed in Escherichia coli pre-incubated for 4 hrs before substrate addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+6nMAssay Description:Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)More data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+6nMAssay Description:Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 0.990nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 0.690nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 3.10nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: >100nMAssay Description:Agonist activity at GPR54 expressed in CHO cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataKd: 282nMAssay Description:pA2 value was evaluated against P2Y purinoceptor 1More data for this Ligand-Target Pair
Affinity DataKd: 77.6nMAssay Description:pA2 value was evaluated against P2Y purinoceptor 1More data for this Ligand-Target Pair
Affinity DataKd: 7.00E+3nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant aft...More data for this Ligand-Target Pair
Affinity DataKd: 400nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant af...More data for this Ligand-Target Pair
Affinity DataKd: 200nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant af...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+3nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant af...More data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant af...More data for this Ligand-Target Pair
Affinity DataKd: 190nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant af...More data for this Ligand-Target Pair
Affinity DataKd: 900nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant af...More data for this Ligand-Target Pair
Affinity DataKd: 600nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant af...More data for this Ligand-Target Pair
Affinity DataKd: 4.70E+3nMAssay Description:Displacement of [3H]-YM09151-2 from dopamine D2 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant af...More data for this Ligand-Target Pair
