TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reade...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reade...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of GLS1 in human A549 cells assessed as reduction in conversion of glutamine to glutamate measured after 24 hrsMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University Of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair