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Found 389 with Last Name = 'evenou' and Initial = 'jp'
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066770((3R,6S,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  111nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066766((3R,6R,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  145nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066769((3R,6R,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  751nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066768((3R,6S,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  1.45E+3nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of CYP3A4-catalyzed midazolam 1'-hydroxylation in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066769((3R,6R,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  3.40E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066773((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  3.58E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066766((3R,6R,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  5.10E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066771((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  5.10E+3nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066767((3R,6R,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  5.36E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066769((3R,6R,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  6.78E+3nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066770((3R,6S,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  7.90E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066772((3R,6R,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  1.03E+4nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066771((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  1.33E+4nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066768((3R,6S,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  1.78E+4nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066773((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  1.95E+4nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066768((3R,6S,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  1.96E+4nMAssay Description:Invitro inhibition was measured against Bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066772((3R,6R,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  2.51E+4nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066766((3R,6R,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  2.60E+4nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066771((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi: >3.37E+4nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066770((3R,6S,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi: >3.37E+4nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066767((3R,6R,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  6.24E+4nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393214(CHEMBL2151411)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of PKCtheta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393214(CHEMBL2151411)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of PKCdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393214(CHEMBL2151411)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393214(CHEMBL2151411)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393218(CHEMBL1996510)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PKCdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393218(CHEMBL1996510)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PKCtheta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393218(CHEMBL1996510)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393218(CHEMBL1996510)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393228(CHEMBL2153750)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PKCdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393228(CHEMBL2153750)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PKCtheta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393214(CHEMBL2151411)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PKCepsilon by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393218(CHEMBL1996510)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PKCepsilon by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33970(maleimide derivative, 12)
Affinity DataIC50:  0.900nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33970(maleimide derivative, 12)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393228(CHEMBL2153750)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKCtheta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393219(CHEMBL2151415)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKCdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393218(CHEMBL1996510)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKCeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393229(CHEMBL2153751)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PKCdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393219(CHEMBL2151415)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PKCtheta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393229(CHEMBL2153751)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PKCtheta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393228(CHEMBL2153750)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1.30nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PKCdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393219(CHEMBL2151415)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393219(CHEMBL2151415)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50393226(CHEMBL2153748)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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