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Found 408 with Last Name = 'carter' and Initial = 'js'
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057581(4-(4-Fluoro-5-phenyl-3-trifluoromethyl-pyrazol-1-y...)
Affinity DataIC50:  1.70nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50435048(CHEMBL2391142)
Affinity DataIC50:  2nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50435046(CHEMBL2391140)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426967(CHEMBL2325079 | PF-4693627)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50435045(CHEMBL2391141)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50435047(CHEMBL2391299)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426967(CHEMBL2325079 | PF-4693627)
Affinity DataIC50:  3nMAssay Description:Inhibition of human mPGES1 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049024(4-[6-(4-Fluoro-phenyl)-spiro[2.4]hept-5-en-5-yl]-b...)
Affinity DataIC50:  3nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057618(4-[5-(3-Methyl-4-methylsulfanyl-phenyl)-3-trifluor...)
Affinity DataIC50:  3.70nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057551(4-[5-(4-Dimethylamino-phenyl)-3-trifluoromethyl-py...)
Affinity DataIC50:  4.70nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sul...)
Affinity DataIC50:  5nMAssay Description:In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sul...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for its inhibitory activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076888(4-[4-(4-Chloro-phenyl)-2-methyl-thiazol-5-yl]-benz...)
Affinity DataIC50:  5nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057554(1,5-Bis-(4-methoxy-phenyl)-3-trifluoromethyl-1H-py...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sul...)
Affinity DataIC50:  5nMAssay Description:In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057606(4-[4-Chloro-5-(4-chloro-phenyl)-3-trifluoromethyl-...)
Affinity DataIC50:  5.30nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057575(4-[5-(4-Dimethylamino-3-fluoro-phenyl)-3-trifluoro...)
Affinity DataIC50:  5.70nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50435044(CHEMBL2391295)
Affinity DataIC50:  6nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076878(5-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426967(CHEMBL2325079 | PF-4693627)
Affinity DataIC50:  6nMAssay Description:Inhibition of mPGES-1 in human fetal fibroblast cells assessed as PGF2alpha level after 50 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057609(4-[2-(4-Methoxy-phenyl)-5-trifluoromethyl-2H-pyraz...)
Affinity DataIC50:  6.70nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076863(2-[3-(4-Bromo-phenyl)-propyl]-4-(4-fluoro-phenyl)-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of mPGES-1-mediated PGE2 production in LPS-stimulated healthy human whole blood after 20 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057589(4-[5-(4-Methoxy-phenyl)-3-trifluoromethyl-pyrazol-...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426956(CHEMBL2325076)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human mPGES1 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057591(4-[5-(4-Methylsulfanyl-phenyl)-3-trifluoromethyl-p...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076880(4-[2-(3,5-Dichloro-phenoxymethyl)-4-(4-fluoro-phen...)
Affinity DataIC50:  9nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057620(4-[5-(4-Methoxy-3-methyl-phenyl)-3-trifluoromethyl...)
Affinity DataIC50:  9.30nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076883(4-[2-Benzylamino-4-(3-fluoro-4-methoxy-phenyl)-thi...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076866(2-(2-Chloro-phenyl)-5-(4-methanesulfonyl-phenyl)-4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057572(4-[4-Chloro-5-(4-chloro-phenyl)-3-cyano-pyrazol-1-...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076868(2-(2-Chloro-phenyl)-4-(2-fluoro-phenyl)-5-(4-metha...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057610(4-[5-(4-Chloro-phenyl)-3-difluoromethyl-pyrazol-1-...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057602(4-[2-(4-Fluoro-phenyl)-5-trifluoromethyl-2H-pyrazo...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057527(4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057552(4-[5-(5-Bromo-thiophen-2-yl)-3-trifluoromethyl-pyr...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057608(4-(3-Difluoromethyl-5-p-tolyl-pyrazol-1-yl)-benzen...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076884(4-[2-(2-Chloro-phenyl)-4-(4-fluoro-phenyl)-thiazol...)
Affinity DataIC50:  13nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426958(CHEMBL2325074)
Affinity DataIC50:  15nMAssay Description:Inhibition of human mPGES1 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50435043(CHEMBL2391296)
Affinity DataIC50:  15nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057562(4-[3-Difluoromethyl-5-(4-methoxy-phenyl)-pyrazol-1...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057560(4-[5-(3,4-Dichloro-phenyl)-3-trifluoromethyl-pyraz...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426955(CHEMBL2325077)
Affinity DataIC50:  16nMAssay Description:Inhibition of human mPGES1 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057573(4-[5-(4-Methylamino-phenyl)-3-trifluoromethyl-pyra...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50435042(CHEMBL2391297)
Affinity DataIC50:  16nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076853(2-(2-Chloro-phenyl)-4-(3-fluoro-phenyl)-5-(4-metha...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076874(2-Benzyl-4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057532(1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-3-trifluo...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50076882(4-[5-(4-Chloro-phenyl)-2-methyl-thiazol-4-yl]-benz...)
Affinity DataIC50:  18nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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