TargetSphingosine kinase 1(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 3.60nMAssay Description:Competitive inhibition of recombinant human C-terminal His-tagged SphK1 expressed in baculovirus infected Sf21 cells using varying concentrations of ...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 6.40E+3nMAssay Description:Inhibition of recombinant SphK2 (unknown origin) using sphingosine as substrate by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 6.90E+3nMAssay Description:Inhibition of recombinant human Flag-tagged SphK2 transfected in HEK293 cells using d-erythro-sphingosine as substrate by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 9.80E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length SphK2 expressed in baculovirus infected Sf9 cells using C17-sphingosine as substrat...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.65E+4nMAssay Description:Inhibition of recombinant SphK2 (unknown origin) using sphingosine as substrate incubated for 15 to 20 mins by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
TargetSphingosine kinase 1(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 2.70E+4nMAssay Description:Inhibition of recombinant human Flag-tagged SphK1 transfected in HEK293 cells using d-erythro-sphingosine as substrate by [gamma32P]-ATP based assayMore data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 234nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 248nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 254nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 261nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 266nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 269nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 359nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 391nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 396nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 452nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 687nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 717nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 909nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SphK2 (2 to 654 residues) expressed in baculovirus infected Sf21 cells using d-erythro-sphingos...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataKd: 878nMAssay Description:Displacement of [3H]Ro15-1788 from rat GABAA alpha1beta2gamma2 receptor expressed in HEK293 cells after 1 hr assessed as residual binding by liquid s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataEC50: 1.10nMAssay Description:Activity at rat wild type GABAA alpha1beta2gamma2 receptor expressed in xenopus oocytes assessed as GABA-elicited response by two electrode voltage c...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataEC50: 250nMAssay Description:Activity at rat wild type GABAA alpha1beta2gamma2 receptor expressed in xenopus oocytes assessed as GABA-elicited response by two electrode voltage c...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataEC50: 191nMAssay Description:Activity at rat wild type GABAA alpha1beta2gamma2 receptor expressed in xenopus oocytes assessed as GABA-elicited response by two electrode voltage c...More data for this Ligand-Target Pair