TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))
Emory University School Of Medicine
Curated by ChEMBL
Emory University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as inhibition con...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))
Emory University School Of Medicine
Curated by ChEMBL
Emory University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as inhibition con...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))
Emory University School Of Medicine
Curated by ChEMBL
Emory University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 5.30nMAssay Description:Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as inhibition con...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))
Emory University School Of Medicine
Curated by ChEMBL
Emory University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))
Emory University School Of Medicine
Curated by ChEMBL
Emory University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))
Emory University School Of Medicine
Curated by ChEMBL
Emory University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 56nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))
Emory University School Of Medicine
Curated by ChEMBL
Emory University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 280nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells measured after 5 to 10 mins post compound washout by PatchXpress automated ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7alpha incubated for 5 mins measured at 10 secs interval by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
University Of Aberdeen
Curated by ChEMBL
University Of Aberdeen
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of IKK beta at 300 uM by K-ELISAMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University of Michigan
Curated by ChEMBL
University of Michigan
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at -120 mV holding potential measured for 8 sec by patch-clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Tested for irreversible inhibitory activity against AdoMet-DC (S-adenosyl-methionine decarboxylase-) isolated from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University of Michigan
Curated by ChEMBL
University of Michigan
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of [3H]PIA binding to rat cortical adenosine A1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of NaV1.7 channel in human DRG neurons assessed as reduction of TTX-sensitive current by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells incubated for 5 mins measured at 10 secs interval by PatchXpress automated ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department of Discovery Chemistry Merck
Curated by ChEMBL
Department of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair