Affinity DataKi: 110nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 260nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 550nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.10E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5.20E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 6.50E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 7.20E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 9.70E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0300nMAssay Description:Competitive inhibition of Chk1 in presence of higher ATP levelsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0300nMAssay Description:Competitive inhibition of Chk1 in presence of higher ATP levelsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of CHK1 by time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of CHK1 by time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of CHK1 by time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0500nMAssay Description:Competitive inhibition of Chk1 in presence of higher ATP levelsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0500nMAssay Description:Competitive inhibition of Chk1 in presence of higher ATP levelsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of CHK1 by time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0500nMAssay Description:Competitive inhibition of Chk1 in presence of higher ATP levelsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of CHK1 by time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.110nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: >0.150nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...More data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against human Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Merck Research Laboratories
Merck Research Laboratories
Affinity DataIC50: 0.200nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.25nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.25nMAssay Description:Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.25nMAssay Description:Inhibition of bovine Farnesyltransferase in vitro.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.270nMAssay Description:Competitive inhibition of Chk1 in presence of higher ATP levelsMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.290nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in cultured Ha-ras transformed RAT1 cells.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of CHK1 by time resolved fluorescence assayMore data for this Ligand-Target Pair