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Found 1079 with Last Name = 'grant' and Initial = 's'
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222915(4'-[5-(4-pyrrolidin-1-ylmethyl-phenylamino)-1H-pyr...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222916(4'-{5-[4-(dimethylamino-methyl)-phenylamino]-2H-py...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222920(4'-{5-[6-(sec-butylamino-methyl)-pyridin-3-ylamino...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222917(4'-[5-(6-piperidin-1-ylmethyl-pyridin-3-ylamino)-1...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222914(4'-[5-(4-cyclopropylaminomethyl-phenylamino)-2H-py...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222921(3-(1H-benzo[d]imidazol-2-yl)-N-(2,4-dihydroxypheny...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222919(4'-(5-{6-[(cyclopropylmethyl-amino)-methyl]-pyridi...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517230(CHEMBL4467984)
Affinity DataKi:  0.840nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517232(CHEMBL4546839)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222918(4'-(5-phenylamino-2H-pyrazol-3-yl)-biphenyl-2,4-di...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM92906(CHK1 compound 1)
Affinity DataKi:  1.75nM ΔG°:  -49.5kJ/molepH: 7.4 T: 2°CAssay Description:The inhibitors reported in this study bind to CHK1 according to a general mechanism illustrated in Scheme 1 where E, S, and I stand for enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517229(CHEMBL4541515)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517236(CHEMBL4465127)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517222(CHEMBL4579585)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to human D2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM92906(CHK1 compound 1)
Affinity DataKi:  5.14nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:Surface plasmon resonance (SPR) biosensor binding studies were conducted using a Biacore 3000 instrument (GE Healtchare).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517233(CHEMBL4568756)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517221(CHEMBL4554135)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517223(CHEMBL4471116)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50010289((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H] spiperone from human D2 dopamine receptor expressed in monkey caudate-putamen membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517226(CHEMBL4449666)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517227(CHEMBL4562705)
Affinity DataKi:  97nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517225(CHEMBL4453578)
Affinity DataKi:  106nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517224(CHEMBL4443273)
Affinity DataKi:  131nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM92908(CHK1 compound 3)
Affinity DataKi:  146nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:The inhibitors reported in this study bind to CHK1 according to a general mechanism illustrated in Scheme 1 where E, S, and I stand for enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517234(CHEMBL4446228)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517235(CHEMBL4444520)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM92908(CHK1 compound 3)
Affinity DataKi:  290nM ΔG°:  -36.7kJ/molepH: 8.0 T: 2°CAssay Description:Surface plasmon resonance (SPR) biosensor binding studies were conducted using a Biacore 3000 instrument (GE Healtchare).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222922(3-(1H-benzo[d]imidazol-2-yl)-N-(4-hydroxyphenyl)-1...)
Affinity DataKi:  301nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Newcastle

LigandPNGBDBM5566(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Affinity DataKi:  1.30E+3nM ΔG°:  -34.2kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517231(CHEMBL4517197)
Affinity DataKi:  1.81E+3nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM92907(CHK1 compound 2)
Affinity DataKi:  1.89E+3nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:The inhibitors reported in this study bind to CHK1 according to a general mechanism illustrated in Scheme 1 where E, S, and I stand for enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCannabinoid receptor 1(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50517228(CHEMBL4461338)
Affinity DataKi:  2.11E+3nMAssay Description:Displacement of [3H]CP55940 from human CB1R in HEK293 cell membranes after 60 mins liquid scintillation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University of Newcastle

LigandPNGBDBM5566(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Affinity DataKi:  2.50E+3nM ΔG°:  -32.5kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University of Newcastle

LigandPNGBDBM5485(6-(cyclohexylmethoxy)-9H-purin-2-amine | CHEMBL269...)
Affinity DataKi:  5.00E+3nM ΔG°:  -30.8kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Newcastle

LigandPNGBDBM5485(6-(cyclohexylmethoxy)-9H-purin-2-amine | CHEMBL269...)
Affinity DataKi:  1.20E+4nM ΔG°:  -28.6kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383996(CHEMBL2032134)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383999(CHEMBL2032137)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383966(CHEMBL2032148)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383998(CHEMBL2032136)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50384000(CHEMBL2032138)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383997(CHEMBL2032135)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396539(CHEMBL2171144)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396542(CHEMBL2171141)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396532(CHEMBL2171126)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396536(CHEMBL2171122)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396540(CHEMBL2171143)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383994(CHEMBL2032132)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383987(CHEMBL2032125)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptide deformylase(Streptococcus pneumoniae serotype 4 (strain ATCC B...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50383982(CHEMBL2032119)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of Streptococcus pneumoniae PDF assessed as formate release from fMAS peptide substrate after 20 mins by formate dehydrogenase coupled ass...More data for this Ligand-Target Pair
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