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Found 94 with Last Name = 'ripa' and Initial = 's'
TargetL-lactate dehydrogenase B chain(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of mouse LDHB using sodium pyruvate as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human LDHA using sodium pyruvate as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50592886(CHEMBL5199516)
Affinity DataKi:  5.46E+3nMAssay Description:Inhibition of LDHA in human liver using pyruvate as substrate incubated for 3 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50592886(CHEMBL5199516)
Affinity DataKi:  1.51E+4nMAssay Description:Inhibition of LDHB in human heart using pyruvate as substrate incubated for 3 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50144744(Sodium Oxamate)
Affinity DataKi:  1.36E+5nMAssay Description:Inhibition of human LDHA using sodium pyruvate as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50253810(CHEMBL459505 | N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1...)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human Fyn using Cdc2 peptide as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of from NanoLuc-fused Fyn (unknown origin) transfected in HEK293 cells using tracer K4 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of from NanoLuc-fused GSK-3-beta (unknown origin) transfected in HEK293 cells using tracer K8 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human GSK-3-beta using phospho GS2 peptide as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50253810(CHEMBL459505 | N-(4-(2-ethyl-1-(1H-1,2,4-triazol-1...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of from NanoLuc-fused GSK-3-beta (unknown origin) transfected in HEK293 cells using tracer K8 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50592885(CHEMBL5206296)
Affinity DataIC50:  12nMAssay Description:Inhibition of LDHA in human Med1 cells using pyruvate as substrate incubated 10 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataIC50:  12nMAssay Description:Inhibition of NanoLuc-fused DYRK1A (unknown origin) transfected in HEK293 cells using tracer K10 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  18nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50577453(CHEMBL4869861)
Affinity DataIC50:  50nMAssay Description:Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157727(CHEMBL3786184)
Affinity DataIC50:  60nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50:  91nMAssay Description:Inhibition of from NanoLuc-fused Fyn (unknown origin) transfected in HEK293 cells using tracer K4 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157721(CHEMBL3786620)
Affinity DataIC50:  110nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157717(CHEMBL3786581)
Affinity DataIC50:  240nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157722(CHEMBL3787323)
Affinity DataIC50:  270nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157611(CHEMBL3787627)
Affinity DataIC50:  340nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50:  360nMAssay Description:Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataIC50:  520nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157722(CHEMBL3787323)
Affinity DataIC50:  680nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50:  903nMAssay Description:Inhibition of human DYRK1A using RRRFRPASPLRGPPK as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157724(CHEMBL3787564 | US9963439, Compound B)
Affinity DataIC50:  930nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157727(CHEMBL3786184)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157721(CHEMBL3786620)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50033067(4-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50033067(4-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157731(CHEMBL3785511 | US9963439, Compound C)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157729(CHEMBL3787691)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM31886(CD564 | CHEMBL309282)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157604(CHEMBL3786324)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157604(CHEMBL3786324)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157605(Liarozole | Liazal | R-75251 | US9963439, Liarozol...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157731(CHEMBL3785511 | US9963439, Compound C)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157729(CHEMBL3787691)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50:  3.77E+3nMAssay Description:Inhibition of NanoLuc-fused DYRK1A (unknown origin) transfected in HEK293 cells using tracer K10 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157724(CHEMBL3787564 | US9963439, Compound B)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157718(CHEMBL3785701)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157608(CHEMBL95949)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157719(CHEMBL3785624)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157723(CHEMBL3786927)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157726(CHEMBL3786043)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157728(CHEMBL3785761)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157730(CHEMBL3785557)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26B1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157608(CHEMBL95949)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50157719(CHEMBL3785624)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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