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Found 163 with Last Name = 'kline' and Initial = 't'
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003319(3-(2-{5-Guanidino-2-[(2-mercapto-benzoyl)-methyl-a...)
Affinity DataKi:  4nMAssay Description:Inhibition of ADP-induced platelet aggregation in canine platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003322(3-(2-{2-[(2-Acetylamino-3-mercapto-propionyl)-meth...)
Affinity DataKi:  175nMAssay Description:Inhibition of ADP-induced platelet aggregation in canine platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003317(CHEMBL339832 | [18-(3-Guanidino-propyl)-2,8,11,14,...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of ADP-induced platelet aggregation in canine platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003321(3-{2-[2-(2-Acetylamino-3-mercapto-propionylamino)-...)
Affinity DataKi:  3.13E+3nMAssay Description:Inhibition of ADP-induced platelet aggregation in canine platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003325(3-{2-[2-(2-Acetylamino-3-mercapto-propionylamino)-...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of [3H]-Mba-(N-Me)Arg-Gly-Asp-Man binding to GPIIb/IIIa from human platelets reconstituted in liposomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003315(CHEMBL421247 | [5-Benzyl-17-(3-guanidino-propyl)-4...)
Affinity DataKi:  1.85E+4nMAssay Description:Inhibition of ADP-induced platelet aggregation in canine platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003314(CHEMBL129782 | [18-(3-Guanidino-propyl)-2,5,11,14,...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of ADP-induced platelet aggregation in canine platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048982((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propi...)
Affinity DataIC50:  0.370nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048970((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.460nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048963((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.570nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048972((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048967((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.75nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048964((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  0.920nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048981((S)-2-({(R)-2-[(S)-2-((R)-3-Mercapto-2-methyl-prop...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048966((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048968((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048969((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048974((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  2.80nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048975((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  4.40nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048963((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50013016(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1-c...)
Affinity DataIC50:  5.40nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH- DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50284172((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50284165((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propyl...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048983((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50083587((S)-2-[(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048970((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058200((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50013018(2-Diazo-1-(7-dipropylamino-5,6,7,8-tetrahydro-naph...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]-8-OH- DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048968((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50013018(2-Diazo-1-(7-dipropylamino-5,6,7,8-tetrahydro-naph...)
Affinity DataIC50:  24nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]-8-OH- DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50284176((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propyl...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048965((S)-2-{(R)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13373((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048973((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  45nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50284169((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  68nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50013017(1-Diazo-3-(7-dipropylamino-5,6,7,8-tetrahydro-naph...)
Affinity DataIC50:  72nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH- DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50013017(1-Diazo-3-(7-dipropylamino-5,6,7,8-tetrahydro-naph...)
Affinity DataIC50:  78nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]-8-OH- DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048962((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  85nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003319(3-(2-{5-Guanidino-2-[(2-mercapto-benzoyl)-methyl-a...)
Affinity DataIC50:  90nMAssay Description:Inhibition of ADP-induced platelet aggregation in canine platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048978((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50013015(CHEMBL176446 | Diazo-acetic acid 7-dipropylamino-5...)
Affinity DataIC50:  107nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH- DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048972((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Chiron

Curated by ChEMBL
LigandPNGBDBM50115465(2-(4-Allyloxy-3-trifluoromethoxy-phenyl)-4,5-dihyd...)
Affinity DataIC50:  120nMAssay Description:Inhibition of P. aeruginosa UDP-3-O-acyl-N-acetylglucosamine Deacetylase (LpxC) in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048977((R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propi...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50284177((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50284174((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  126nMAssay Description:In vitro inhibitory concentration evaluated against P21ras Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Mount Sinai School of Medicine

Curated by ChEMBL
LigandPNGBDBM50013015(CHEMBL176446 | Diazo-acetic acid 7-dipropylamino-5...)
Affinity DataIC50:  155nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH- DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048980((S)-2-{(E)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibitory activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Chiron

Curated by ChEMBL
LigandPNGBDBM50115478(2-(4-Methoxy-3-trifluoromethoxy-phenyl)-4,5-dihydr...)
Affinity DataIC50:  160nMAssay Description:Inhibition of P. aeruginosa UDP-3-O-acyl-N-acetylglucosamine Deacetylase (LpxC) in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Chiron

Curated by ChEMBL
LigandPNGBDBM50115438(2-[4-(3-Methyl-but-2-enyloxy)-3-trifluoromethoxy-p...)
Affinity DataIC50:  190nMAssay Description:Inhibition of P. aeruginosa UDP-3-O-acyl-N-acetylglucosamine Deacetylase (LpxC) in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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