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Found 1789 with Last Name = 'koudriakova' and Initial = 't'
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028059(CHEMBL3338866)
Affinity DataKi:  0.5nMAssay Description:Displacement of (S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-((3H)-1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2 rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321465((6-(3-chlorophenoxy)pyridin-3-yl)(4-cyclobutyl-1,4...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321467((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321503((5-(3,4-dichlorophenoxy)pyridin-2-yl)(4-isopropyl-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50561646(CHEMBL4798102)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321466(3-(5-(4-cyclobutyl-1,4-diazepane-1-carbonyl)pyridi...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50097380(CHEMBL3586432)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254203(US10112937, Example 88 | US10150765, Example 88 | ...)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321496((4-cyclobutyl-1,4-diazepan-1-yl)(6-(phenylthio)pyr...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321463((4-cyclobutyl-1,4-diazepan-1-yl)(5-(4-fluorophenox...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM64682(US9475819, 10A)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409484(1-(Azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)p...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321497((4-cyclobutyl-1,4-diazepan-1-yl)(5-(phenylthio)pyr...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321468((4-cyclobutyl-1,4-diazepan-1-yl)(6-(3-fluorophenox...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409560(2-[6-(5-Chloro-4-methyl-2-thienyl)pyrrolo[3,2-b]py...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321498((4-cyclobutyl-1,4-diazepan-1-yl)(5-(2-fluorophenox...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321472((4-cyclobutyl-1,4-diazepan-1-yl)(6-phenoxypyridin-...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321469((4-cyclobutyl-1,4-diazepan-1-yl)(5-(4-fluorophenyl...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321500((5-(3-chlorophenoxy)pyridin-2-yl)(4-cyclobutyl-1,4...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US10112937, Example 158 | US10150765, Example 158 ...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-A-804598 from recombinant human P2X7 expressed in human 1321N1 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254266(US10112937, Example 158 | US10150765, Example 158 ...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-A-804598 from recombinant rat P2X7 expressed in human 1321N1 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50412863(CHEMBL359632 | JNJ-10397049)
Affinity DataKi:  5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50509848(CHEMBL4547576)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50203731(CHEMBL3973097)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321501((5-(4-chlorophenoxy)pyridin-2-yl)(4-cyclobutyl-1,4...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321499((4-cyclobutyl-1,4-diazepan-1-yl)(5-(3-fluorophenox...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321488((4-cyclobutyl-1,4-diazepan-1-yl)(4-(4-fluorophenox...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataKi:  6nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254160(US10112937, Example 40 | US10150765, Example 40 | ...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-(S)-7-(2-chloro-3-(trifluoromethyl)benzyl)-6-methyl-3-(pyrazin-2-yl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one from re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50097388(CHEMBL3586426)
Affinity DataKi:  7nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254160(US10112937, Example 40 | US10150765, Example 40 | ...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-(S)-7-(2-chloro-3-(trifluoromethyl)benzyl)-6-methyl-3-(pyrazin-2-yl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one from re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321471((4-cyclobutyl-1,4-diazepan-1-yl)(6-(3,4-dichloroph...)
Affinity DataKi:  7.60nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409128(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50097360(CHEMBL3586440)
Affinity DataKi:  8nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM163902(US9062078, 33 | US9475819, 33 | US9637496, 33 | US...)
Affinity DataKi:  8.70nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM65032(US9475819, 279)
Affinity DataKi:  9nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50097388(CHEMBL3586426)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50092814(CHEMBL3586436)
Affinity DataKi:  10nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321502((4-cyclopropyl-1,4-diazepan-1-yl)(5-(3,4-dichlorop...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321507((4-cyclopropyl-1,4-diazepan-1-yl)(6-phenoxypyridin...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321471((4-cyclobutyl-1,4-diazepan-1-yl)(6-(3,4-dichloroph...)
Affinity DataKi:  10nMAssay Description:Binding affinity to histamine H3 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50092813(CHEMBL3586434)
Affinity DataKi:  10nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50092812(CHEMBL3586433)
Affinity DataKi:  10nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50092814(CHEMBL3586436)
Affinity DataKi:  10nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM163879(US9062078, 11 | US9062078, 12A | US9062078, 12B | ...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM163876(US9062078, 10A | US9062078, 10B | US9062078, 9 | U...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409482(1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321491((4-cyclobutyl-1,4-diazepan-1-yl)(5-phenoxypyridin-...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]-iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409275(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50321466(3-(5-(4-cyclobutyl-1,4-diazepane-1-carbonyl)pyridi...)
Affinity DataKi:  11nMAssay Description:Binding affinity to histamine H3 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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