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Found 159 with Last Name = 'ding' and Initial = 'vd'
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334486(CHEMBL1643951 | trans-4-((1-(4-tert-butylcyclohexy...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171818(4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorometho...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161488(CHEMBL439289 | Des-His1[Glu9]glucagon-NH2)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration towards binding of [125I]-glucagon to the human glucagon receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161488(CHEMBL439289 | Des-His1[Glu9]glucagon-NH2)
Affinity DataIC50:  18nMAssay Description:Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171817(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144009(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)
Affinity DataIC50:  21nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334495((R)-3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorom...)
Affinity DataIC50:  28nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171839(4-{3-[1-(4-Bromo-phenyl)-ethyl]-8-tert-butyl-2-oxo...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171814(4-[8-tert-Butyl-2-oxo-3-(3-trifluoromethoxy-phenyl...)
Affinity DataIC50:  33nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171819(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  34nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50410091(CHEMBL2112992)
Affinity DataIC50:  34nMAssay Description:Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334480(4-((5-(3,5-dichlorophenyl)-3-(4-(trifluoromethoxy)...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171829(4-[8-tert-Butyl-3-(3,5-dichloro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  36nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334480(4-((5-(3,5-dichlorophenyl)-3-(4-(trifluoromethoxy)...)
Affinity DataIC50:  36nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334482(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluoromethoxy)...)
Affinity DataIC50:  39nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161498(4-Cyano-5-(2-ethyl-butyrylamino)-3-methyl-thiophen...)
Affinity DataIC50:  41nMAssay Description:Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171820(3-{4-[8-tert-Butyl-3-(3,5-dichloro-phenyl)-2-oxo-1...)
Affinity DataIC50:  43nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334478(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol...)
Affinity DataIC50:  43nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50:  44nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334486(CHEMBL1643951 | trans-4-((1-(4-tert-butylcyclohexy...)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334486(CHEMBL1643951 | trans-4-((1-(4-tert-butylcyclohexy...)
Affinity DataIC50:  46nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171818(4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorometho...)
Affinity DataIC50:  46nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334478(4-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol...)
Affinity DataIC50:  47nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161497(CHEMBL178768 | N-{3-Cyano-6-[(2,4-dichloro-benzyl)...)
Affinity DataIC50:  59nMAssay Description:Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171834(3-{4-[8-tert-Butyl-2-oxo-3-(3-trifluoromethoxy-phe...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161496(CHEMBL179181 | N-{3-Cyano-6-[(2,4-dichloro-benzyl)...)
Affinity DataIC50:  63nMAssay Description:Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334476(CHEMBL1644178 | trans-4-((5-(4-tert-butylcyclohexy...)
Affinity DataIC50:  63nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171828(4-[8-tert-Butyl-3-(3,4-difluoro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  65nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334481(3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluorometho...)
Affinity DataIC50:  84nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50410091(CHEMBL2112992)
Affinity DataIC50:  89nMAssay Description:Inhibitory concentration towards binding of [125I]-glucagon to the human glucagon receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171835(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  92nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161496(CHEMBL179181 | N-{3-Cyano-6-[(2,4-dichloro-benzyl)...)
Affinity DataIC50:  92nMAssay Description:Inhibitory concentration towards binding of [125I]-glucagon to the human glucagon receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171819(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  92nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171825(4-[8-tert-Butyl-3-(3-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  94nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334479(3-(4-((5-(3,5-dichlorophenyl)-3-(4-(trifluorometho...)
Affinity DataIC50:  95nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171836(4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  105nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171831(4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50:  113nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171815(4-[8-tert-Butyl-3-(4-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  116nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171829(4-[8-tert-Butyl-3-(3,5-dichloro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  116nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334483(CHEMBL1644186 | N-((2H-tetrazol-5-yl)methyl)-4-((3...)
Affinity DataIC50:  120nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334490(4-((5-cyclohexyl-3-(4-(trifluoromethoxy)phenyl)-1H...)
Affinity DataIC50:  120nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161497(CHEMBL178768 | N-{3-Cyano-6-[(2,4-dichloro-benzyl)...)
Affinity DataIC50:  129nMAssay Description:Inhibitory concentration towards binding of [125I]-glucagon to the human glucagon receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161494(CHEMBL179281 | N-[3-Cyano-6-(1,1-dimethyl-propyl)-...)
Affinity DataIC50:  129nMAssay Description:Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334484(4-(1-(3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyraz...)
Affinity DataIC50:  130nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171831(4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50:  135nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161489(CHEMBL182148 | N-{3-Cyano-6-[methyl-(1,2,3,4-tetra...)
Affinity DataIC50:  139nMAssay Description:Inhibitory concentration towards binding of [125I]-glucagon to the human glucagon receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161489(CHEMBL182148 | N-{3-Cyano-6-[methyl-(1,2,3,4-tetra...)
Affinity DataIC50:  139nMAssay Description:Inhibitory concentration towards binding of [125I]-glucagon to the human glucagon receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144009(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171817(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)
Affinity DataIC50:  144nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161498(4-Cyano-5-(2-ethyl-butyrylamino)-3-methyl-thiophen...)
Affinity DataIC50:  153nMAssay Description:Inhibitory concentration towards binding of [125I]-glucagon to the human glucagon receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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