Compile Data Set for Download or QSAR
maximum 50k data
Found 899 with Last Name = 'schubert' and Initial = 'w'
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013216((racemic)Sodium salt of7-[4-(4-Fluoro-phenyl)-1,2-...)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50007261(CHEMBL102091 | Sodium; 7-[4-(4-fluoro-phenyl)-2-is...)
Affinity DataIC50: <0.0100nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013210(CHEMBL162642 | Sodium salt of 7-[4-(4-Fluoro-pheny...)
Affinity DataIC50:  0.0140nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013217(CHEMBL159951 | Sodium salt of7-[1-Cyclohexyl-4-(4-...)
Affinity DataIC50:  0.0180nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013212(CHEMBL160102 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50004774((S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-[2-(...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013219(CHEMBL2375155 | Sodium salt of7-[1-Cyclohexyl-4-(4...)
Affinity DataIC50:  0.106nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013219(CHEMBL2375155 | Sodium salt of7-[1-Cyclohexyl-4-(4...)
Affinity DataIC50:  0.106nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013221(CHEMBL163277 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013220(CHEMBL161829 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637195(US20230382904, Compound 115)
Affinity DataIC50:  1.30nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637184(US20230382904, Compound 104)
Affinity DataIC50:  1.70nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637157(US20230382904, Compound 77)
Affinity DataIC50:  1.80nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637196(US20230382904, Compound 116)
Affinity DataIC50:  2.20nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637109(US20230382904, Compound 29 | US20230382904, Compou...)
Affinity DataIC50:  2.30nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637108(US20230382904, Compound 28 | US20230382904, Compou...)
Affinity DataIC50:  2.40nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637109(US20230382904, Compound 29 | US20230382904, Compou...)
Affinity DataIC50:  2.80nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637203(US20230382904, Compound 123)
Affinity DataIC50:  2.90nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637244(US20230382904, Compound 159)
Affinity DataIC50:  2.90nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013211((racemic)Sodium salt of7-[4-(4-Fluoro-phenyl)-2-is...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637192(2-Amino-N-[(2S)-butan-2-yl]-6-(5-{[(1S)-1-(4-fluor...)
Affinity DataIC50:  3.20nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637168(US20230382904, Compound 88)
Affinity DataIC50:  3.20nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637171(US20230382904, Compound 91)
Affinity DataIC50:  3.30nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637108(US20230382904, Compound 28 | US20230382904, Compou...)
Affinity DataIC50:  3.40nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637247(US20230382904, Compound 162)
Affinity DataIC50:  3.5nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637169(US20230382904, Compound 89)
Affinity DataIC50:  3.70nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637188(US20230382904, Compound 108)
Affinity DataIC50:  4nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637237(US20230382904, Compound 152)
Affinity DataIC50:  4.15nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637218(US20230382904, Compound 138)
Affinity DataIC50:  4.20nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637240(US20230382904, Compound 155)
Affinity DataIC50:  4.30nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637182(US20230382904, Compound 102)
Affinity DataIC50:  4.30nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637139(US20230382904, Compound 59)
Affinity DataIC50:  4.35nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637221(US20230382904, Compound 141 | US20230382904, Compo...)
Affinity DataIC50:  4.60nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637105(US20230382904, Compound 25)
Affinity DataIC50:  4.61nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637174(2-Amino-N-[(2S)-butan-2-yl]-6-(5-{[(1S)-1-(4-fluor...)
Affinity DataIC50:  4.75nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637123(US20230382904, Compound 43 | US20230382904, Compou...)
Affinity DataIC50:  4.85nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637239(US20230382904, Compound 154)
Affinity DataIC50:  4.90nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013222(CHEMBL159103 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013214((racemic)Sodium salt of7-[4-(4-Fluoro-phenyl)-2-is...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013214((racemic)Sodium salt of7-[4-(4-Fluoro-phenyl)-2-is...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637156(US20230382904, Compound 76)
Affinity DataIC50:  5.15nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637140(US20230382904, Compound 60)
Affinity DataIC50:  5.25nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637187(US20230382904, Compound 107)
Affinity DataIC50:  5.5nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637121(US20230382904, Compound 41)
Affinity DataIC50:  5.5nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637219(US20230382904, Compound 139)
Affinity DataIC50:  5.5nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637180(US20230382904, Compound 100)
Affinity DataIC50:  5.80nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013218(CHEMBL345375 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50007261(CHEMBL102091 | Sodium; 7-[4-(4-fluoro-phenyl)-2-is...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein delta homolog 1(Homo sapiens (Human))
The Johns Hopkins University

US Patent
LigandPNGBDBM637202(US20230382904, Compound 122)
Affinity DataIC50:  6nMAssay Description:Assay Protocol for 1536 MTP format: test compounds were predispensed (60 nl) in test plates; +3 μl DLK solution (10 nM DLK, catalytic domain, Ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50013213(CHEMBL350103 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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