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Found 560 with Last Name = 'seo' and Initial = 'y'
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50568146(CHEMBL1481541)
Affinity DataKi:  3.10nMAssay Description:Noncompetitive inhibition of mushroom tyrosinase assessed as dissociation constant using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntestinal-type alkaline phosphatase(Bos taurus (Cattle))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50275870(CHEMBL4129331)
Affinity DataKi:  115nMAssay Description:Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as enzyme-inhibitor dissociation constant using varying levels of p-NPP as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50135168(3,4,5-Trihydroxy-benzoic acid (2R,3S)-5,7-dihydrox...)
Affinity DataKi:  170nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50135163(3,4,5-Trihydroxy-benzoic acid (2S,3S)-5,7-dihydrox...)
Affinity DataKi:  210nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntestinal-type alkaline phosphatase(Bos taurus (Cattle))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50275870(CHEMBL4129331)
Affinity DataKi:  415nMAssay Description:Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as enzyme-substrate-inhibitor dissociation constant using varying levels of p-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50283374(CHEMBL4169273)
Affinity DataKi:  1.10E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured up to 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50494304(CHEMBL3086710)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of recombinant human Hsp90alpha ATP-binding pocket of N-terminal domain after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50214969(1,3,6-Trihydroxy-7-methoxy-2,8-bis-(3-methyl-but-2...)
Affinity DataKi:  2.85E+3nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50241453(1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)-9...)
Affinity DataKi:  3.17E+3nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50135164(3,4,5-Trihydroxy-benzoic acid (2S,3S)-2-(3,4-dihyd...)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibitory activity of the compound against recombinant human Beta-secretase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataKi:  1.20E+4nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50108112(CHEMBL3601648)
Affinity DataKi:  1.30E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-inhibitor dissociation constant preincubated for 10 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50133593(CHEMBL3261712)
Affinity DataKi:  1.74E+4nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50108113(CHEMBL3601649)
Affinity DataKi:  4.10E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-inhibitor dissociation constant preincubated for 10 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50108112(CHEMBL3601648)
Affinity DataKi:  5.30E+4nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-substrate-inhibitor dissociation constant preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50108114(CHEMBL3601650)
Affinity DataKi:  6.00E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-inhibitor dissociation constant preincubated for 10 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50108109(CHEMBL3601645)
Affinity DataKi:  6.50E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-inhibitor dissociation constant preincubated for 10 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50108113(CHEMBL3601649)
Affinity DataKi:  1.00E+5nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-substrate-inhibitor dissociation constant preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50108109(CHEMBL3601645)
Affinity DataKi:  2.05E+5nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-substrate-inhibitor dissociation constant preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50568146(CHEMBL1481541)
Affinity DataIC50:  3nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50464556(CHEMBL4289811 | US10464907, Compound 21f | US10889...)
Affinity DataIC50:  5.30nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University

US Patent
LigandPNGBDBM50464556(CHEMBL4289811 | US10464907, Compound 21f | US10889...)
Affinity DataIC50:  5.30nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50464556(CHEMBL4289811 | US10464907, Compound 21f | US10889...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(RAT)
University Of Melbourne

Curated by ChEMBL
LigandPNGBDBM50169743((13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pe...)
Affinity DataIC50:  5.89nMAssay Description:Displacement of [3H]estradiol from rat uterine cytosolic estrogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University

US Patent
LigandPNGBDBM50464557(CHEMBL4279132 | US10464907, Compound 21e | US10889...)
Affinity DataIC50:  6.5nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50464557(CHEMBL4279132 | US10464907, Compound 21e | US10889...)
Affinity DataIC50:  6.5nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50464557(CHEMBL4279132 | US10464907, Compound 21e | US10889...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50170264(CHEMBL361931 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Affinity DataIC50:  8.40nMAssay Description:Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50464562(CHEMBL4293186 | US10464907, Compound 21d | US10889...)
Affinity DataIC50:  11nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University

US Patent
LigandPNGBDBM50464562(CHEMBL4293186 | US10464907, Compound 21d | US10889...)
Affinity DataIC50:  11.4nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50464562(CHEMBL4293186 | US10464907, Compound 21d | US10889...)
Affinity DataIC50:  11.4nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50008059(CHEBI:5292 | GELDANAMYCIN)
Affinity DataIC50:  14nMAssay Description:Inhibition of fluorescein isothiocyanate labeled geldanamycin binding to N-terminal domain of full length human recombinant Hsp90alpha expressed in E...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50008059(CHEBI:5292 | GELDANAMYCIN)
Affinity DataIC50:  14nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chonbuk National University

Curated by ChEMBL
LigandPNGBDBM50114826(8-(4-Methoxy-phenyl)-8-oxo-octanoic acid hydroxyam...)
Affinity DataIC50:  15nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50568147(CHEMBL4877433)
Affinity DataIC50:  18nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50568150(CHEMBL4857732)
Affinity DataIC50:  19nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Industry-Academic Cooperation Foundation Yonsei University

US Patent
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50:  21nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAnoctamin-1(Homo sapiens (Human))
Industry-Academic Cooperation Foundation Yonsei University

US Patent
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50:  21nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAnoctamin-1(Homo sapiens (Human))
Industry-Academic Cooperation Foundation Yonsei University

US Patent
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50:  22nMAssay Description:Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiologica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50568149(CHEMBL4878458)
Affinity DataIC50:  23nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50592766(CHEMBL5175785)
Affinity DataIC50:  24nMAssay Description:Inhibition of His-tagged N-terminal recombinant HSP90alpha (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50568151(CHEMBL4849416)
Affinity DataIC50:  27nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM20800(2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4...)
Affinity DataIC50:  29nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50592758(CHEMBL5188138)
Affinity DataIC50:  31nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorogenic substrate incubated for 30 mins by fluorescence plate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University

US Patent
LigandPNGBDBM419585(US10464907, Compound 21g | US10889552, Compound 21...)
Affinity DataIC50:  33nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM419585(US10464907, Compound 21g | US10889552, Compound 21...)
Affinity DataIC50:  33nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50207416(CHEMBL3891745)
Affinity DataIC50:  36nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20321(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Affinity DataIC50:  37nMAssay Description:Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University

Curated by ChEMBL
LigandPNGBDBM50568144(CHEMBL4867234)
Affinity DataIC50:  39nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50172566(CHEMBL196291 | N-{4-[3-(4-tert-Butyl-benzyl)-thiou...)
Affinity DataIC50:  41nMAssay Description:Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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