TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Noncompetitive inhibition of mushroom tyrosinase assessed as dissociation constant using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Bos taurus (Cattle))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataKi: 115nMAssay Description:Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as enzyme-inhibitor dissociation constant using varying levels of p-NPP as sub...More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
Affinity DataKi: 210nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Bos taurus (Cattle))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataKi: 415nMAssay Description:Mixed-type inhibition of calf intestinal alkaline phosphatase assessed as enzyme-substrate-inhibitor dissociation constant using varying levels of p-...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 1.10E+3nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured up to 5 ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataKi: 2.80E+3nMAssay Description:Inhibition of recombinant human Hsp90alpha ATP-binding pocket of N-terminal domain after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Dongguk University
Curated by ChEMBL
Dongguk University
Curated by ChEMBL
Affinity DataKi: 2.85E+3nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Dongguk University
Curated by ChEMBL
Dongguk University
Curated by ChEMBL
Affinity DataKi: 3.17E+3nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
Affinity DataKi: 5.30E+3nMAssay Description:Inhibitory activity of the compound against recombinant human Beta-secretase 1More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Dongguk University
Curated by ChEMBL
Dongguk University
Curated by ChEMBL
Affinity DataKi: 1.20E+4nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 1.30E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-inhibitor dissociation constant preincubated for 10 mins f...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Dongguk University
Curated by ChEMBL
Dongguk University
Curated by ChEMBL
Affinity DataKi: 1.74E+4nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 4.10E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-inhibitor dissociation constant preincubated for 10 mins f...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 5.30E+4nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-substrate-inhibitor dissociation constant preincubated...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 6.00E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-inhibitor dissociation constant preincubated for 10 mins f...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 6.50E+4nMAssay Description:Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-inhibitor dissociation constant preincubated for 10 mins f...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 1.00E+5nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-substrate-inhibitor dissociation constant preincubated...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataKi: 2.05E+5nMAssay Description:Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as enzyme-substrate-inhibitor dissociation constant preincubated...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University
US Patent
Industry Academic Cooperation Foundation Keimyung University
US Patent
Affinity DataIC50: 5.30nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
Affinity DataIC50: 5.89nMAssay Description:Displacement of [3H]estradiol from rat uterine cytosolic estrogen receptorMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University
US Patent
Industry Academic Cooperation Foundation Keimyung University
US Patent
Affinity DataIC50: 6.5nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutesMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University
US Patent
Industry Academic Cooperation Foundation Keimyung University
US Patent
Affinity DataIC50: 11.4nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 11.4nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of fluorescein isothiocyanate labeled geldanamycin binding to N-terminal domain of full length human recombinant Hsp90alpha expressed in E...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
TargetAnoctamin-1(Homo sapiens (Human))
Industry-Academic Cooperation Foundation Yonsei University
US Patent
Industry-Academic Cooperation Foundation Yonsei University
US Patent
Affinity DataIC50: 21nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
TargetAnoctamin-1(Homo sapiens (Human))
Industry-Academic Cooperation Foundation Yonsei University
US Patent
Industry-Academic Cooperation Foundation Yonsei University
US Patent
Affinity DataIC50: 21nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
TargetAnoctamin-1(Homo sapiens (Human))
Industry-Academic Cooperation Foundation Yonsei University
US Patent
Industry-Academic Cooperation Foundation Yonsei University
US Patent
Affinity DataIC50: 22nMAssay Description:Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiologica...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged N-terminal recombinant HSP90alpha (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by fluoresce...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorogenic substrate incubated for 30 mins by fluorescence plate readerMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Bovine)
Industry Academic Cooperation Foundation Keimyung University
US Patent
Industry Academic Cooperation Foundation Keimyung University
US Patent
Affinity DataIC50: 33nMAssay Description:Fluorescence polarization assay was performed to confirm the binding ability to the compound synthesized with HSP90 according the concentration. 1 M ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Endonuclease activity assays were carried out in Black Costar 96-well plates. Each well contained a total volume of 100 μL comprised of: buffer ...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of FITC-labeled geldanamycin binding to human Hsp90alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutesMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Kongju National University
Curated by ChEMBL
Kongju National University
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrateMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibitory effect on capsaicin (0.5 uM)-induced calcium uptake in rat DRG neurons upon incubation at RT for 10 minutesMore data for this Ligand-Target Pair