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Found 201 with Last Name = 'adam' and Initial = 'gc'
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50258579((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569630(CHEMBL4873847)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406127(CHEMBL5290844)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50:  1.70nMAssay Description:Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]More data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569630(CHEMBL4873847)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15559((2S)-2-[4-({[(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluo...)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50258579((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569643(CHEMBL4867665)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569643(CHEMBL4867665)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569643(CHEMBL4867665)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406126(CHEMBL5291288)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50258579((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406123(CHEMBL5277419)
Affinity DataIC50:  7nMAssay Description:In vitro Oxytocin receptor antagonistic activity against rat uterine stripsMore data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15560((2S)-2-[4-({[(2S)-1-[(3R)-3-amino-4-(2,3,4,5,6-pen...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569630(CHEMBL4873847)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory activity against bovine cathepsin DMore data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569642(CHEMBL4879154)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Mus musculus)TBA
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50:  17nMAssay Description:Inhibition of Choline AcetyltransferaseMore data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569642(CHEMBL4879154)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Mus musculus)TBA
LigandPNGBDBM50406130(CHEMBL5272946)
Affinity DataIC50:  21nMAssay Description:Inhibition of Choline AcetyltransferaseMore data for this Ligand-Target Pair
In DepthDetails
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406132(CHEMBL5273314)
Affinity DataIC50:  21nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15561((3R)-3-amino-4-(5-chloro-2-fluorophenyl)-1-[3-(tri...)
Affinity DataIC50:  21nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406137(CHEMBL5286066)
Affinity DataIC50:  32nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406136(CHEMBL5278676)
Affinity DataIC50:  32nMAssay Description:In vitro inhibitory activity against aspartic proteinases pepsin from porcineMore data for this Ligand-Target Pair
In DepthDetails
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406134(CHEMBL5275403)
Affinity DataIC50:  32nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406133(CHEMBL5288633)
Affinity DataIC50:  32nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406138(CHEMBL5286071)
Affinity DataIC50:  33nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15562((2S)-2-[4-({[(2S)-1-[(3R)-3-amino-4-(5-fluoro-2-me...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406130(CHEMBL5272946)
Affinity DataIC50:  34nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406131(CHEMBL5278405)
Affinity DataIC50:  35nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406135(CHEMBL5278640)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15563(2-[4-({[(4R)-3-[(3R)-3-amino-4-(2-fluorophenyl)but...)
Affinity DataIC50:  37nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569642(CHEMBL4879154)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50593123(GENZ-682452 | GZ-402671 | GZ/SAR402671 | GZ402671 ...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569641(CHEMBL4872186)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50:  55nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406119(CHEMBL5273405)
Affinity DataIC50:  85nMAssay Description:In vitro Oxytocin receptor antagonistic activity against rat uterine stripsMore data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50:  87nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15564((3R)-3-amino-1-(1,3-thiazolidin-3-yl)-4-(2,4,5-tri...)
Affinity DataIC50:  119nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569630(CHEMBL4873847)
Affinity DataIC50:  120nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569641(CHEMBL4872186)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569633(CHEMBL4851511)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM15565(DPP-4 ligand 7 | methyl 2-[4-({[(2S)-1-[(3R)-3-ami...)
Affinity DataIC50:  170nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50406128(CHEMBL5270537)
Affinity DataIC50:  180nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50258579((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569641(CHEMBL4872186)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))TBA
LigandPNGBDBM50406130(CHEMBL5272946)
Affinity DataIC50:  224nMAssay Description:In vitro inhibitory potency against human kidney renin.More data for this Ligand-Target Pair
In DepthDetails
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