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Found 1383 with Last Name = 'bürli' and Initial = 'r'
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479267(US10894789, Compound 66)
Affinity DataIC50:  1nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479289(US10894789, Compound 233)
Affinity DataIC50:  1nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264437(CHEMBL488984 | N-(2-aminopyrimidin-5-yl)-6-chloro-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50260888(3-(2-aminoquinazolin-6-yl)-1-(2-cyclopentylethyl)-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-Kit (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264392(CHEMBL490823 | N-(6-acetamidopyridin-3-yl)-6-chlor...)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365966(CHEMBL1956237)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365980(CHEMBL1956251)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365982(CHEMBL1956253)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365967(CHEMBL1956238)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365974(CHEMBL1956245)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365977(CHEMBL1956248)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479241(US10894789, Compound 185)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264391(CHEMBL523816 | N-(6-aminopyridin-3-yl)-6-chloro-3-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479268(US10894789, Compound 65)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479282(US10894789, Compound 221)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479169(US10894789, Compound 125)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479176(US10894789, Compound 123)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479203(US10894789, Compound 78)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479227(US10894789, Compound 211)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479229(US10894789, Compound 120)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479230(US10894789, Compound 21)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243125(CHEMBL487864 | N3-(6-acetamidopyridin-3-yl)-4-meth...)
Affinity DataIC50:  2nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365964(CHEMBL1956235 | CHEMBL2070530)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479243(US10894789, Compound 169)
Affinity DataIC50:  2nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50260890(3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of c-Kit (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365968(CHEMBL1956239)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365973(CHEMBL1956244)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365975(CHEMBL1956246)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479308(US10894789, Compound 264)
Affinity DataIC50:  3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479239(US10894789, Compound 30)
Affinity DataIC50:  3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479157(US10894789, Compound 197)
Affinity DataIC50:  3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479174(US10894789, Compound 63)
Affinity DataIC50:  3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479190(US10894789, Compound 23)
Affinity DataIC50:  3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479201(US10894789, Compound 150)
Affinity DataIC50:  3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264220(2-(1,6-diphenyl-1H-imidazo[4,5-c]pyridine-4-carbox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251959(2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-h...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365956(CHEMBL1956228)
Affinity DataIC50:  3nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264439(6-chloro-N-(pyridin-3-yl)-3-(3-(trifluoromethyl)ph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365978(CHEMBL1956249)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479238(US10894789, Compound 31)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264363(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethoxy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479272(US10894789, Compound 216)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479273(US10894789, Compound 217)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479158(US10894789, Compound 175)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479159(US10894789, Compound 174)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479165(US10894789, Compound 29)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479168(US10894789, Compound 124)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479169(US10894789, Compound 125)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM479175(US10894789, Compound 134)
Affinity DataIC50:  4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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