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Found 114 with Last Name = 'bauer' and Initial = 'mr'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335827((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391946(CHEMBL2147763)
Affinity DataIC50:  2nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335827((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50505077(CHEMBL4588064)
Affinity DataIC50:  2nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391948(CHEMBL2147767)
Affinity DataIC50:  2nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391938(CHEMBL2147845)
Affinity DataIC50:  3nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50113472(CHEMBL3603919 | US10246432, Example 2 | US10584111...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)
Affinity DataIC50:  4nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843((5R,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843((5R,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50505076(CHEMBL4530560)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843((5R,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843((5R,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335830((6R,12aS)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335827((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335846((5R,11aR)5-(3,4-Dichlorophenyl)-2-tert-butyl-5,6,1...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50113471(CHEMBL3603918)
Affinity DataIC50:  20nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50505078(CHEMBL4590482)
Affinity DataIC50:  26nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335823((6R,12aR)6-(2,4-Dichlorophenyl)-2-methyl-2,3,6,7,1...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335826((6R,12aS)6-(2,4-Dichlorophenyl)-2-methyl-2,3,6,7,1...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391944(CHEMBL2147769)
Affinity DataIC50:  53nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335845((5R,11aS)5-(2,4-Dichlorophenyl)-2-tert-butyl-5,6,1...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335855((5S,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391949(CHEMBL2147768)
Affinity DataIC50:  92nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335827((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  104nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50505075(CHEMBL4443751)
Affinity DataIC50:  120nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335857((5R,11aR)5-(3,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335838((6R,12aR)6-(2,4-Dichlorophenyl)-2-tert-butyl-2,3,6...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335841((6R,12aS)6-(2,4-Dichlorophenyl)-2-tert-butyl-2,3,6...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335828((6S,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335834((6R,12aR)6-(2,4-Dichlorophenyl)-2-butyl-2,3,6,7,12...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335837((6R,12aS)6-(2,4-Dichlorophenyl)-2-butyl-2,3,6,7,12...)
Affinity DataIC50:  290nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335857((5R,11aR)5-(3,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cAMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335843((5R,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant PDE11A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335851((1S,3S)Methyl 1-(2,4-Dichlorophenyl)-2-(2-chloroac...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391945(CHEMBL2147770)
Affinity DataIC50:  447nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335853((1R,3S)Methyl-1-(2,4-Dichlorophenyl)-2,3,4,9-tetra...)
Affinity DataIC50:  570nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335845((5R,11aS)5-(2,4-Dichlorophenyl)-2-tert-butyl-5,6,1...)
Affinity DataIC50:  590nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335822((1S,3S)Methyl 1-(2,6-Dichlorophenyl)-2-(2-chloroac...)
Affinity DataIC50:  730nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335825((6S,12aS)6-(2,4-Dichlorophenyl)-2-methyl-2,3,6,7,1...)
Affinity DataIC50:  850nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335855((5S,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a...)
Affinity DataIC50:  850nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335829((6S,12aS)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  990nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335835((6S,12aR)6-(2,4-Dichlorophenyl)-2-butyl-2,3,6,7,12...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335824((6S,12aR)6-(2,4-Dichlorophenyl)-2-methyl-2,3,6,7,1...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335839((6S,12aR)6-(2,4-Dichlorophenyl)-2-tert-butyl-2,3,6...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335842((6R,12aS)6-(3,4-Dichlorophenyl)-2-tert-butyl-2,3,6...)
Affinity DataIC50:  1.27E+3nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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