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Found 583 with Last Name = 'bradley' and Initial = 'p'
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079941((8-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50035948(2-[3-(4-Acetylamino-benzenesulfonylamino)-2-oxo-6-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037360(2-(2-Oxo-6-phenyl-3-phenylmethanesulfonylamino-2H-...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079939((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...)
Affinity DataKi:  1.60nMAssay Description:The compound was tested for binding affinity against human Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037348(1N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)-2-(3-...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity of the compound to the dopamine receptor D2L in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036058(CHEMBL354883 | benzyl (S)-1-((S)-2-(((S)-1,1,1-tri...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079945((2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1-(2,3-...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50058391((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079950(CHEMBL430698 | N-(2,3-Dihydro-benzo[1,4]dioxin-2-y...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079939((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...)
Affinity DataKi:  3.60nMAssay Description:The compound was tested for binding affinity against 5-hydroxytryptamine 1A receptor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037364(CHEMBL113187 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50036127(CHEMBL11391 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037344(3-{2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  5.10nMAssay Description:Binding affinity of the compound to the dopamine receptor D2L in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037341(4-{2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-1-isopropyl-...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50035944(2-(3-Benzenesulfonylamino-2-oxo-6-phenyl-2H-pyridi...)
Affinity DataKi:  6nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079940(CHEMBL324076 | [1-(2,3-Dihydro-benzo[1,4]dioxin-2-...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity of the compound to the dopamine receptor D2L in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079940(CHEMBL324076 | [1-(2,3-Dihydro-benzo[1,4]dioxin-2-...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity of the compound to the dopamine receptor D2L in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037371(2-[2-Oxo-6-phenyl-3-(2-pyridin-2-yl-ethanesulfonyl...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079947((2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1-(3-me...)
Affinity DataKi:  7nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037372(2-[3-(3-Benzyl-ureido)-2-oxo-6-phenyl-2H-pyridin-1...)
Affinity DataKi:  7nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12287(SCH 491762 | tert-butyl N-[(1S)-2-[(1R,2S,5S)-2-[(...)
Affinity DataKi:  8nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037375(CHEMBL275043 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50035951(2-[3-(4-Methoxy-benzenesulfonylamino)-2-oxo-6-phen...)
Affinity DataKi:  8.40nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037361(2-(3-Ethylamino-2-oxo-6-phenyl-2H-pyridin-1-yl)-N-...)
Affinity DataKi:  8.70nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037354(CHEMBL113905 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro...)
Affinity DataKi:  8.80nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037355(2-(3-Methanesulfonylamino-2-oxo-6-phenyl-2H-pyridi...)
Affinity DataKi:  9.30nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037351(2-[3-(3-Acetylamino-benzenesulfonylamino)-2-oxo-6-...)
Affinity DataKi:  9.40nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12309((1R,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxo...)
Affinity DataKi:  13nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037359(4-({2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-1-isopropyl...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037343(2-[2-Oxo-6-phenyl-3-(pyridin-4-ylmethanesulfonylam...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079939((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...)
Affinity DataKi:  13.2nMAssay Description:The compound was tested for binding affinity against human Dopamine receptor D2LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12311((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  14nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037353(CHEMBL326238 | {2-Oxo-6-phenyl-1-[(3,3,3-trifluoro...)
Affinity DataKi:  15nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037365(2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-...)
Affinity DataKi:  15nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037368(2-(2-Oxo-6-phenyl-3-phenylacetylamino-2H-pyridin-1...)
Affinity DataKi:  15nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037366(2-[2-Oxo-6-phenyl-3-(3-pyridin-2-ylmethyl-ureido)-...)
Affinity DataKi:  15nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079955((2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1-(4-me...)
Affinity DataKi:  15nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  15.7nMAssay Description:Binding affinity of the compound to the dopamine receptor D2L in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12307((1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  16nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037352(2-[2-Oxo-6-phenyl-3-((S)-3-pyridin-4-ylmethyl-urei...)
Affinity DataKi:  16nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079950(CHEMBL430698 | N-(2,3-Dihydro-benzo[1,4]dioxin-2-y...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound to the dopamine receptor D2L in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079951((8-Fluoro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079952(CHEMBL112526 | [1-(2-Chloro-phenyl)-piperidin-4-yl...)
Affinity DataKi:  17nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037342(1N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)-2-(3-...)
Affinity DataKi:  18nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50037362(2-({2-Oxo-6-phenyl-1-[(3,3,3-trifluoro-1-isopropyl...)
Affinity DataKi:  18nMAssay Description:Binding affinity against human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079946((2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1-(2,3-...)
Affinity DataKi:  18nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079944(CHEMBL114852 | [1-(2,3-Dihydro-benzo[1,4]dioxin-2-...)
Affinity DataKi:  20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Knoll Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50079940(CHEMBL324076 | [1-(2,3-Dihydro-benzo[1,4]dioxin-2-...)
Affinity DataKi:  21nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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