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Found 610 with Last Name = 'busch-petersen' and Initial = 'j'
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M3 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50053265((6aR,9R,10aR)-3-((Z)-Hept-1-enyl)-9-hydroxymethyl-...)
Affinity DataKi:  0.800nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 1 enriched rat brain microsome prepara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50053266((6aR,9R,10aR)-3-((E)-Hept-1-enyl)-9-hydroxymethyl-...)
Affinity DataKi:  1.20nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 1 enriched rat brain microsome prepara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066705((6R,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-6,9-bis-h...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066705((6R,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-6,9-bis-h...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066709((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxy...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066710((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxy...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066706((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-6-(2-hydr...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066712((6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxymet...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066712((6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxymet...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066706((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-6-(2-hydr...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  3.16nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066709((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxy...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066710((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxy...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50053266((6aR,9R,10aR)-3-((E)-Hept-1-enyl)-9-hydroxymethyl-...)
Affinity DataKi:  5.30nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 2 enriched mouse spleen preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50053267((6aR,9R,10aR)-3-Hept-1-ynyl-9-hydroxymethyl-6,6-di...)
Affinity DataKi:  5.80nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 1 enriched rat brain microsome prepara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50053268((6aR,9R,10aR)-3-Heptyl-9-hydroxymethyl-6,6-dimethy...)
Affinity DataKi:  8.70nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 1 enriched rat brain microsome prepara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50053265((6aR,9R,10aR)-3-((Z)-Hept-1-enyl)-9-hydroxymethyl-...)
Affinity DataKi:  9.5nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 2 enriched mouse spleen preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066708((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxy...)
Affinity DataKi:  9.70nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066707((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-6-ethyl-9...)
Affinity DataKi:  11.1nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50053268((6aR,9R,10aR)-3-Heptyl-9-hydroxymethyl-6,6-dimethy...)
Affinity DataKi:  14nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 2 enriched mouse spleen preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066711((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxy...)
Affinity DataKi:  14.4nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066707((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-6-ethyl-9...)
Affinity DataKi:  21.5nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  31.6nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066711((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxy...)
Affinity DataKi:  38.9nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 2 from mouse spleen was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM60994((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Affinity DataKi:  39nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 2 enriched mouse spleen preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50066708((6S,6aR,9R,10aR)-3-(1,1-Dimethyl-heptyl)-9-hydroxy...)
Affinity DataKi:  40.7nMAssay Description:Binding affinity of the compound to Cannabinoid receptor 1 from rat forebrain synaptosomal membranes was measured using [3H]CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM60994((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Affinity DataKi:  48nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 1 enriched rat brain microsome prepara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
University Of Hawaii

Curated by ChEMBL
LigandPNGBDBM50053267((6aR,9R,10aR)-3-Hept-1-ynyl-9-hydroxymethyl-6,6-di...)
Affinity DataKi:  62nMAssay Description:Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 2 enriched mouse spleen preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413103(CHEMBL555474)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413103(CHEMBL555474)
Affinity DataIC50:  2.51nMAssay Description:Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413132(CHEMBL554918)
Affinity DataIC50:  2.51nMAssay Description:Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413131(CHEMBL540400)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413136(CHEMBL466271)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193985(3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193979(3-{[[(2-bromophenyl)amino](cyanoimino)methyl]amino...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413125(CHEMBL486983)
Affinity DataIC50:  5.01nMAssay Description:Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced intracellular ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413141(CHEMBL539885)
Affinity DataIC50:  5.01nMAssay Description:Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413133(CHEMBL495102)
Affinity DataIC50:  5.01nMAssay Description:Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50193972(3-(2-bromophenyl)-2-cyano-1-(2-hydroxy-4-methyl-3-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]IL8 from CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401890(CHEMBL2206606)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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