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Found 462 with Last Name = 'colas' and Initial = 'c'
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM13211((3S,6S,9aS)-6-[(2S)-2-aminobutanamido]-N-(diphenyl...)
Affinity DataKi:  25nM ΔG°:  -43.1kJ/mole IC50:  460nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM13212((3S,6S,9aS)-N-(diphenylmethyl)-6-[(2S)-2-(methylam...)
Affinity DataKi:  61nM ΔG°:  -40.9kJ/mole IC50:  530nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Milano

LigandPNGBDBM26205((3S,6S,7R,9aS)-6-[(2S)-2-aminobutanamido]-7-(2-ami...)
Affinity DataKi:  220nM ΔG°:  -37.6kJ/mole IC50:  250nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Milano

LigandPNGBDBM26203((3S,6S,7S,9aS)-6-[(2S)-2-aminobutanamido]-N-(diphe...)
Affinity DataKi:  250nM ΔG°:  -37.3kJ/mole IC50:  270nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
LigandPNGBDBM50003399(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Affinity DataKi:  350nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Milano

LigandPNGBDBM13211((3S,6S,9aS)-6-[(2S)-2-aminobutanamido]-N-(diphenyl...)
Affinity DataKi:  420nM ΔG°:  -36.0kJ/mole IC50:  460nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP [241-356](Homo sapiens (Human))
University of Milano

LigandPNGBDBM26204((3S,6S,7R,9aS)-6-[(2S)-2-aminobutanamido]-7-(amino...)
Affinity DataKi:  870nM ΔG°:  -34.2kJ/mole IC50:  970nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234288(CHEMBL4085113)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470054(CHEMBL129225)
Affinity DataKi:  3.30E+3nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470049(CHEMBL340682)
Affinity DataKi:  6.70E+3nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470051(CHEMBL339044)
Affinity DataKi:  9.70E+3nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470050(CHEMBL129170)
Affinity DataKi:  9.80E+3nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470048(CHEMBL128291)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470060(CHEMBL125789)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470059(CHEMBL338840)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470058(CHEMBL129005)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470057(CHEMBL129336)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470055(CHEMBL125790)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470052(CHEMBL127108)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470047(CHEMBL50135)
Affinity DataKi: >1.00E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470053(CHEMBL125621)
Affinity DataKi:  1.16E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470056(CHEMBL129006)
Affinity DataKi:  1.45E+4nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234283(CHEMBL4060165)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234285(CHEMBL4083894)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234284(CHEMBL4083473)
Affinity DataKi:  3.80E+4nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234291(CHEMBL4068819)
Affinity DataKi:  7.30E+4nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234287(CHEMBL4100876)
Affinity DataKi:  7.70E+4nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234280(CHEMBL4071517)
Affinity DataKi:  8.30E+4nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234279(CHEMBL4078902)
Affinity DataKi:  1.77E+5nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234278(CHEMBL4103180)
Affinity DataKi:  1.90E+5nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234282(CHEMBL4097017)
Affinity DataKi:  1.95E+5nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234286(CHEMBL4064465)
Affinity DataKi:  2.20E+5nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234292(CHEMBL4080252)
Affinity DataKi:  3.60E+5nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234290(CHEMBL4098554)
Affinity DataKi:  3.73E+5nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmino acid transporter(Rattus norvegicus)
Binghamton University

Curated by ChEMBL
LigandPNGBDBM50234289(CHEMBL4068036)
Affinity DataKi:  2.00E+6nMAssay Description:Inhibition of rat ASCT2 expressed in HEK293 cells assessed as inhibition of L-alanine/Na+ exchange by measuring reduction in SCN anion inward current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538576(CHEMBL4634092)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538571(CHEMBL4635160)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538560(CHEMBL4640002)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538572(CHEMBL4649132)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538575(CHEMBL4638458)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538562(CHEMBL4643330)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538578(CHEMBL4640729)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538579(CHEMBL4647217)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538582(CHEMBL4638998)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538570(CHEMBL4638573)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Fondazione Irccs Istituto Nazionale Dei Tumori

Curated by ChEMBL
LigandPNGBDBM50401475(CHEMBL2205248)
Affinity DataIC50:  1.10nMAssay Description:Displacement of FITC-Smac from human recombinant His-tagged cIAP-1 BIR3 domain (245 to 357 residues) after 3 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538563(CHEMBL4648116)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538564(CHEMBL4641569)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538583(CHEMBL4643112)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Fondazione Irccs Istituto Nazionale Dei Tumori

Curated by ChEMBL
LigandPNGBDBM50401484(CHEMBL2204575)
Affinity DataIC50:  1.40nMAssay Description:Displacement of FITC-Smac from human recombinant His-tagged cIAP-1 BIR3 domain (245 to 357 residues) after 3 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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