Found 341 with Last Name = 'cox' and Initial = 'pb' 
Affinity DataKi: <0.0100nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0440nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0550nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: <1nMpH: 8.0 T: 2°CAssay Description:Assays were performed in 384-well clear bottom plates (Corning; catalog no. 3702), that contained inhibitor solvated in DMSO. To each well of the pla...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 8.0 T: 2°CAssay Description:Assays were performed in 384-well clear bottom plates (Corning; catalog no. 3702), that contained inhibitor solvated in DMSO. To each well of the pla...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 80nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 80nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 110nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
Affinity DataIC50: 119nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 120nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 120nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 120nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
Affinity DataIC50: 125nMpH: 8.0 T: 2°CAssay Description:Assays were performed in 384-well clear bottom plates (Corning; catalog no. 3702), that contained inhibitor solvated in DMSO. To each well of the pla...More data for this Ligand-Target Pair
Affinity DataIC50: 128nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 130nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 140nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 140nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 140nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 140nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
Affinity DataIC50: 146nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human TRPV3 expressed in recombinant HEK293 cells assessed as inhibition of 2-APB induced calcium flux by FLIPR analysisMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 160nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 160nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 160nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 160nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
Affinity DataIC50: 163nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 170nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 170nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 170nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 180nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 180nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
Affinity DataIC50: 189nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 190nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 190nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 200nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 220nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 220nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 230nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 230nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 230nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 250nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 260nMAssay Description:Experiments were conducted using the FLIPRTETRAŽ. On the day prior to the experiment, recombinant HEK293 cells that stably express human and mouse TR...More data for this Ligand-Target Pair
