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Found 33 with Last Name = 'cozier' and Initial = 'ge'
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataKi:  1.20nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataKi:  4.80nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50189452((S)-2-((S)-6-amino-1-((S)-1-carboxy-2-(1H-indol-3-...)
Affinity DataKi:  9nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50085452((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
Affinity DataKi:  14nMAssay Description:Inhibition of human testis ACE C-domain lacking unique O-glycosylated region, transmembrane anchor and cytoplasmic tail expressed in CHO cells using ...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583450(CHEMBL5077796)
Affinity DataKi:  35nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583449(CHEMBL5075705)
Affinity DataKi:  100nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583450(CHEMBL5077796)
Affinity DataKi:  120nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50085452((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
Affinity DataKi:  172nMAssay Description:Inhibition of human somatic ACE N-domain soluble form (1 to 629 residues) expressed in CHO cells using Z-FHL as substrate preincubated with enzyme fo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583451(CHEMBL5075686)
Affinity DataKi:  440nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50583450(CHEMBL5077796)
Affinity DataKi:  600nMAssay Description:Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50189452((S)-2-((S)-6-amino-1-((S)-1-carboxy-2-(1H-indol-3-...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583451(CHEMBL5075686)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583449(CHEMBL5075705)
Affinity DataKi:  3.79E+3nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50527969(CHEMBL4462603)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of human testis ACE C-domain lacking unique O-glycosylated region, transmembrane anchor and cytoplasmic tail expressed in CHO cells using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50527969(CHEMBL4462603)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of human somatic ACE N-domain soluble form (1 to 629 residues) expressed in CHO cells using Z-FHL as substrate preincubated with enzyme fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50583449(CHEMBL5075705)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50583451(CHEMBL5075686)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50189452((S)-2-((S)-6-amino-1-((S)-1-carboxy-2-(1H-indol-3-...)
Affinity DataKi: >1.50E+5nMAssay Description:Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50085452((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of NEP (unknown origin)More data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat kidney NEP using dansyl-Gly-Phe-Arg as substrate by fluorometric assayMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human NEP using MCA-RPPGFSAFK-Dnp-OH as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50034842((2R,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human NEP using MCA-RPPGFSAFK-Dnp-OH as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  34nMAssay Description:Inhibition of rat kidney NEP using glutaryl-Ala-Ala-beta-naphthylamide as substrate preincubated with enzyme for 15 mins followed by substrate additi...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50468032(CHEMBL4294217)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using MCA-RPPGFSAFK(Dnp)-OH as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50468032(CHEMBL4294217)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using MCA-RPPGFSAFK(Dnp)-OH as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50468032(CHEMBL4294217)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50468032(CHEMBL4294217)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of human ACE using MCA-RPPGFSAFK-Dnp-OH as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50034842((2R,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ACE using MCA-RPPGFSAFK-Dnp-OH as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed