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Found 32 with Last Name = 'd''auria' and Initial = 'm'
TargetPhospholipase A2(Apis mellifera)
Università

Curated by ChEMBL
LigandPNGBDBM50269843(Bolinaquinone | CHEMBL477692)
Affinity DataIC50:  100nMAssay Description:Inhibition of bee venom group 3 secretory phospholipase A2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50269843(Bolinaquinone | CHEMBL477692)
Affinity DataIC50:  200nMAssay Description:Inhibition of human synovial recombinant group 2 secretory phospholipase A2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Università

Curated by ChEMBL
LigandPNGBDBM50269843(Bolinaquinone | CHEMBL477692)
Affinity DataIC50:  400nMAssay Description:Inhibition of pig pancreatic group 1 secretory phospholipase A2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50269844(CHEMBL517216 | Dysidine)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human synovial recombinant group 2 secretory phospholipase A2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50577910(CHEMBL4866994)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 5-LO in A23187/AA-stimulated human intact neutrophils assessed as reduction in LTB4/5-HETE formation measured after 20 mins by RP-HPLC ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50577910(CHEMBL4866994)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of mPGES-1 obtained from IL-beta stimulated human A549 cells microsomes assessed as residual activity by measuring conversion of PGH2 to P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human synovial recombinant group 2 secretory phospholipase A2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50260202(CHEMBL451090 | myricetin 7-O-alpha-L-rhamnopyranos...)
Affinity DataIC50:  6.13E+3nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50260201(CHEMBL503182 | myricetin 7-O-beta-D-glucopyranosyl...)
Affinity DataIC50:  6.52E+3nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Apis mellifera)
Università

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of bee venom group 3 secretory phospholipase A2 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50022445(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(3,4,5-tr...)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50187133(3,4,5-Trihydroxy-benzoic acid methyl ester | CHEMB...)
Affinity DataIC50:  1.55E+4nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50242283(3,4-dihydroxymethylbenzoate | CHEMBL486027 | Methy...)
Affinity DataIC50:  2.96E+4nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50240383((E)-3-(3,4-Dihydroxy-phenyl)-propenal | CHEMBL1729...)
Affinity DataIC50:  3.15E+4nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50240367(3-Hydroxy-4-methoxy-benzaldehyde | 3-hydroxy-4-met...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50241354(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(3,4,5-tr...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50209100(4-hydroxymethylbenzoate | CHEMBL325372 | Methyl pa...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of xanthine oxidase (unknown origin)-mediated formation of uric acid by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50398351(CHEMBL2178583)
Affinity DataEC50:  1.00E+4nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50398353(CHEMBL2178596)
Affinity DataEC50:  5.00E+3nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50448129(CHEMBL3122144)
Affinity DataEC50:  2.10E+4nMAssay Description:Agonist activity at human full-length PXR transfected in human HepG2 cells co-transfected with pSG5-RXR assessed as induction of transactivation by d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50347620(RIFAXIMIN | Rifacol | Rifaxidin)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human full-length PXR transfected in human HepG2 cells co-transfected with pSG5-RXR assessed as induction of transactivation by d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50448128(CHEMBL3122141)
Affinity DataEC50:  1.80E+4nMAssay Description:Agonist activity at human full-length PXR transfected in human HepG2 cells co-transfected with pSG5-RXR assessed as induction of transactivation by d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50434773(CHEMBL2386488)
Affinity DataEC50:  3.00E+4nMAssay Description:Transactivation of FXR (unknown origin) expressed in human HepG2 cells co-expressing RXR assessed as beta-galactosidase activity after 18 hrs by luci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50434774(CHEMBL2386485)
Affinity DataEC50:  2.50E+4nMAssay Description:Antagonist activity at FXR (unknown origin) expressed in human HepG2 cells co-expressing RXR assessed as inhibition of CDCA-induced transactivation a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50351162(CHEMBL1818098 | CHEMBL1818099)
Affinity DataEC50:  2.40E+4nMAssay Description:Antagonist activity at FXR (unknown origin) expressed in human HepG2 cells co-expressing RXR assessed as inhibition of CDCA-induced transactivation a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50011369(CHEMBL3260994)
Affinity DataEC50:  1.00E+3nMAssay Description:Transactivation of human FXR transfected in human HepG2 cells by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataEC50:  100nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50347620(RIFAXIMIN | Rifacol | Rifaxidin)
Affinity DataEC50:  2.20E+3nMAssay Description:Transactivation of human PXR expressed in HepG2 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50347619(CHEMBL1649712 | Solomonsterol A)
Affinity DataEC50:  5.20E+3nMAssay Description:Transactivation of human PXR expressed in HepG2 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50011369(CHEMBL3260994)
Affinity DataEC50:  200nMAssay Description:Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50398352(CHEMBL2178586)
Affinity DataEC50:  2.00E+3nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed