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Found 2115 with Last Name = 'da settimo' and Initial = 'f'
TargetAdenosine deaminase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50370598(CHEMBL1651379)
Affinity DataKi:  0.0530nMAssay Description:Inhibitory constant against bovine spleen Adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50171394(2-Decyl-2H-pyrazolo[3,4-d]pyrimidin-4-ylamine | CH...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory constant against bovine spleen Adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50253857(CHEMBL460998 | N-butyl-2-(5-chloro-2-(4-chlorophen...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50318267(4-methoxy-N-(2-methyl-6-phenyl-2H-pyrazolo[3,4-d]p...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50253893(2-(5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl)-N-me...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.220nMAssay Description:The membranes prepared from CHO cells transfected with human adenosine A3 receptors were used in binding assays. Nonspecific binding was determined i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125I]AB-MECA from human A3 adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM198126((2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methyla...)
Affinity DataKi:  0.220nM ΔG°:  -55.1kJ/molepH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (90 ug) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 5 mM MgCl2, 1 mM EDTA, 2 un...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cell membrane after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50253483(CHEMBL492686 | N,N-dihexyl-2-(2-(4-nitrophenyl)-1H...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50011484(CHEMBL3261894)
Affinity DataKi:  0.235nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50253344(CHEMBL493301 | N,N-dibutyl-2-(2-(4-nitrophenyl)-1H...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50171396(1-((R)-4-Amino-pyrazolo[3,4-d]pyrimidin-2-yl)-deca...)
Affinity DataKi:  0.280nMAssay Description:Inhibitory constant against bovine spleen Adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50421116(CHEMBL2088374)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to TSPO (unknown origin) relative to controlMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50335260(CHEMBL1651226 | N,N-dihexyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.299nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50335259(CHEMBL1651225 | N,N-dibutyl-2-(1-methyl-2-phenyl-1...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104776(CHEMBL3597377)
Affinity DataKi:  0.310nMAssay Description:Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50253894(CHEMBL517895 | N-butyl-2-(5-chloro-2-(4-chlorophen...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104772(CHEMBL3597381)
Affinity DataKi:  0.370nMAssay Description:Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22038(2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...)
Affinity DataKi:  0.370nM ΔG°:  -50.0kJ/molepH: 7.4 T: 2°CAssay Description:Assays were performed by incubating aliquots of rat kidney mitochondria suspensions with [3H]PK 11195 and a range of concentrations of the test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22038(2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...)
Affinity DataKi:  0.370nMAssay Description:Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22038(2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50253595(2-(5-fluoro-2-phenyl-1H-indol-3-yl)-N,N-dihexyl-2-...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50011498(CHEMBL3261908)
Affinity DataKi:  0.442nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50171395(2-Undecyl-2H-pyrazolo[3,4-d]pyrimidin-4-ylamine | ...)
Affinity DataKi:  0.470nMAssay Description:Inhibitory constant against bovine spleen Adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50011495(CHEMBL3261905)
Affinity DataKi:  0.489nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membrane after 180 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50588817(CHEMBL5193551)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-flunitrazepam from TSPO receptor in Wistar rat brain without cerebellum incubated for 90 mins by liquid scintillation counter an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21216(2-[4-(ethylsulfanyl)-1H-1,3-benzodiazol-2-yl]quino...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21216(2-[4-(ethylsulfanyl)-1H-1,3-benzodiazol-2-yl]quino...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50060095(2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Universit£

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]CHA from adenosine A1 receptors was determined in bovine cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:Assays were performed by incubating aliquots of rat kidney mitochondria suspensions with [3H]PK 11195 and a range of concentrations of the test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104771(CHEMBL3597382)
Affinity DataKi:  0.510nMAssay Description:Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104770(CHEMBL3597383)
Affinity DataKi:  0.510nMAssay Description:Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104774(CHEMBL3597379)
Affinity DataKi:  0.520nMAssay Description:Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104779(CHEMBL3597374)
Affinity DataKi:  0.530nMAssay Description:Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104775(CHEMBL3597378)
Affinity DataKi:  0.540nMAssay Description:Inhibition of [3H]PK11195 binding to TSPO in rat kidney mitochondrial membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50143231(2-[2-(4-Chloro-phenyl)-1H-indol-3-yl]-N,N-dihexyl-...)
Affinity DataKi:  0.550nMAssay Description:Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50341403(CHEMBL4173265)
Affinity DataKi:  0.550nMAssay Description:Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50253715(CHEMBL518662 | N-benzyl-N-ethyl-2-(2-(4-nitropheny...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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