Compile Data Set for Download or QSAR
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Found 71 with Last Name = 'donnelly' and Initial = 'dj'
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50123490(CHEMBL143418 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.0420nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50123504(CHEMBL142546 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50123496(CHEMBL143138 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50067797(CHEMBL19080 | L-37378 | N-(6-Amino-2-methyl-pyridi...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50123500(CHEMBL143139 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of Thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130216(CHEMBL3632874)
Affinity DataKi:  5nMAssay Description:Inhibition of human Thrombin using S-2238 as substrate assessed as release of p-nitroaniline preincubated for 240 secs followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130256(CHEMBL3632875)
Affinity DataKi:  8nMAssay Description:Inhibition of human Thrombin using S-2238 as substrate assessed as release of p-nitroaniline preincubated for 240 secs followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130307(CHEMBL3633035)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]CP55940 from mouse brain membrane CB1 receptor after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130296(CHEMBL3632876)
Affinity DataKi:  15nMAssay Description:Inhibition of human Thrombin using S-2238 as substrate assessed as release of p-nitroaniline preincubated for 240 secs followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50400862(CHEMBL2205015)
Affinity DataKi:  19nMAssay Description:Inhibition of FKBP12 (unknown origin)-mediated rotamase activity by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130306(CHEMBL3633034)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]CP55940 from mouse brain membrane CB1 receptor after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130213(CHEMBL3632871)
Affinity DataKi:  57nMAssay Description:Inhibition of human Thrombin using H-D-Phe-Pip-Arg-paranitroanilide/methylsulfonyl-D-Leu-Gly-Arg-paranitroanilide as substrate by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130215(CHEMBL3632873)
Affinity DataKi:  65nMAssay Description:Inhibition of human Thrombin using S-2238 as substrate assessed as release of p-nitroaniline preincubated for 240 secs followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130211(CHEMBL3632869)
Affinity DataKi:  270nMAssay Description:Inhibition of human Thrombin using H-D-Phe-Pip-Arg-paranitroanilide/methylsulfonyl-D-Leu-Gly-Arg-paranitroanilide as substrate by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130212(CHEMBL3632870)
Affinity DataKi:  360nMAssay Description:Inhibition of human Thrombin using H-D-Phe-Pip-Arg-paranitroanilide/methylsulfonyl-D-Leu-Gly-Arg-paranitroanilide as substrate by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130214(CHEMBL3632872)
Affinity DataKi:  590nMAssay Description:Inhibition of human Thrombin using H-D-Phe-Pip-Arg-paranitroanilide/methylsulfonyl-D-Leu-Gly-Arg-paranitroanilide as substrate by spectrophotometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130309(CHEMBL3633037)
Affinity DataKi:  2.40E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi Trypanothione reductase by photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130310(CHEMBL3633038)
Affinity DataKi:  2.80E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi Trypanothione reductase by photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130308(CHEMBL3633036)
Affinity DataKi:  8.40E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi Trypanothione reductase by photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-aminobutyrate aminotransferase, mitochondrial(Sus scrofa)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50082127(3-(ammoniomethyl)-2,6-difluorobenzenolate | 3-Amin...)
Affinity DataKi:  6.30E+6nMAssay Description:Competitive inhibition of pig brain GABA aminotransferase by Dixon/Cornish-Bowden plot analysis in presence of GABAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target4-aminobutyrate aminotransferase, mitochondrial(Sus scrofa)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50073151(4-(ammoniomethyl)-2,6-difluorobenzenolate | 4-Amin...)
Affinity DataKi:  1.10E+7nMAssay Description:Competitive inhibition of pig brain GABA aminotransferase by Dixon/Cornish-Bowden plot analysis in presence of GABAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  0.140nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50065419(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130304(CHEMBL3632865)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human plasma DPP-4 using Gly-Pro-4-methylcoumaryl-7-amide as substrate assessed as formation of 7-amino-4-methylcoumarin after 2 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130302(CHEMBL3632867)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human plasma DPP-4 using Gly-Pro-4-methylcoumaryl-7-amide as substrate assessed as formation of 7-amino-4-methylcoumarin after 2 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50065417(3-[3-(4-Benzyl-4-fluoro-piperidin-1-yl)-propyl]-5-...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130305(CHEMBL3632864)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human plasma DPP-4 using Gly-Pro-4-methylcoumaryl-7-amide as substrate assessed as formation of 7-amino-4-methylcoumarin after 2 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068794(6-(5-Bromo-thiophen-2-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50:  5nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068794(6-(5-Bromo-thiophen-2-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50:  10nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50065417(3-[3-(4-Benzyl-4-fluoro-piperidin-1-yl)-propyl]-5-...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  18nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068792(6-(Thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-yl...)
Affinity DataIC50:  18nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50065419(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068792(6-(Thiophen-2-ylmethoxy)-6,9-dihydro-1H-purin-2-yl...)
Affinity DataIC50:  30nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068785(6-(Thiazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50:  33nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  40nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068786(6-(2-Chloro-pyridin-4-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50:  40nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068786(6-(2-Chloro-pyridin-4-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50:  50nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM14497(2-Pyridone 14b | N-[(4-carbamimidoylphenyl)methyl]...)
Affinity DataIC50:  52nMAssay Description:Inhibition of recombinant human Tissue factor/factor 7a using N-methylsulfonyl-D-phe-gly-arg-p-nitroaniline as substrate assessed as release of p-nit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068785(6-(Thiazol-5-ylmethoxy)-6,9-dihydro-1H-purin-2-yla...)
Affinity DataIC50:  60nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068784(6-(Isothiazol-4-ylmethoxy)-6,9-dihydro-1H-purin-2-...)
Affinity DataIC50:  70nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068784(6-(Isothiazol-4-ylmethoxy)-6,9-dihydro-1H-purin-2-...)
Affinity DataIC50:  70nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068783(6-(Furan-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylami...)
Affinity DataIC50:  80nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068789(6-([1,3]Dioxolo[4,5-b]pyridin-6-ylmethoxy)-6,9-dih...)
Affinity DataIC50:  90nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM5491(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)
Affinity DataIC50:  100nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130314(CHEMBL3633040)
Affinity DataIC50:  112nMAssay Description:Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068793(6-(6-Chloro-pyridin-3-ylmethoxy)-6,9-dihydro-1H-pu...)
Affinity DataIC50:  120nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50068783(6-(Furan-2-ylmethoxy)-6,9-dihydro-1H-purin-2-ylami...)
Affinity DataIC50:  120nMAssay Description:O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50130311(CHEMBL3633039)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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