Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli)
Victoria University Of Wellington
Curated by ChEMBL
Victoria University Of Wellington
Curated by ChEMBL
Affinity DataKi: 0.00200nMAssay Description:Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate assessed as inhibition...More data for this Ligand-Target Pair
Affinity DataKi: 0.00200nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00300nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00500nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00680nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
Affinity DataKi: 0.00700nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00900nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00900nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.0100nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.0160nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
Affinity DataKi: 0.0230nMAssay Description:Inhibitory activity of compound against bovine purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
Affinity DataKi: 0.0260nMAssay Description:Compound was tested for inhibition of hog kidney reninMore data for this Ligand-Target Pair
Affinity DataKi: 0.0290nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Inhibitory activity of compound against bovine purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
Affinity DataKi: 0.0316nMAssay Description:Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.0340nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine
US Patent
Albert Einstein College of Medicine
US Patent
Affinity DataKi: 0.0350nM ΔG°: -59.7kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine
US Patent
Albert Einstein College of Medicine
US Patent
Affinity DataKi: 0.0350nM ΔG°: -59.7kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0400nMAssay Description:Inhibition of purified human kidney renin, radioimmunoassay using a synthetic tetradecapeptide renin substrate at 10e-9 M concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Inhibitory activity of compound against bovine purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Industrial Research
Industrial Research
Affinity DataKi: 0.0480nM ΔG°: -58.3kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli)
Victoria University Of Wellington
Curated by ChEMBL
Victoria University Of Wellington
Curated by ChEMBL
Affinity DataKi: 0.0480nMAssay Description:Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate by xanthine oxidase co...More data for this Ligand-Target Pair
Affinity DataKi: 0.0501nMAssay Description:Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0501nMAssay Description:Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0501nMAssay Description:Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Inhbitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
Affinity DataKi: 0.0600nMAssay Description:Inhibitory activity of compound against bovine purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
Affinity DataKi: 0.0631nMAssay Description:Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0631nMAssay Description:Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0640nMAssay Description:Inhibition of purified human kidney renin, fluorometric assay using a synthetic tetradecapeptide renin substrate at 10e-9 M concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 0.0640nMAssay Description:Compound was tested for inhibition of human kidney reninMore data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0720nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine
US Patent
Albert Einstein College of Medicine
US Patent
Affinity DataKi: 0.0720nM ΔG°: -57.9kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine
US Patent
Albert Einstein College of Medicine
US Patent
Affinity DataKi: 0.0760nM ΔG°: -57.8kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine
US Patent
Albert Einstein College of Medicine
US Patent
Affinity DataKi: 0.0760nM ΔG°: -57.8kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.0780nMAssay Description:Inhibition of human MTAP using methylthioadenosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex...More data for this Ligand-Target Pair
Affinity DataKi: 0.0794nMAssay Description:Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Inhibition of human MTAP as equilibrium dissociation constantMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine
US Patent
Albert Einstein College of Medicine
US Patent
Affinity DataKi: 0.0960nM ΔG°: -57.2kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0960nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine
US Patent
Albert Einstein College of Medicine
US Patent
Affinity DataKi: 0.0960nM ΔG°: -57.2kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
Affinity DataKi: 0.104nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP)More data for this Ligand-Target Pair