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Found 161 with Last Name = 'flanagan' and Initial = 'nj'
TargetHigh affinity choline transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]hemicholinium-3 from recombinant human choline transporter after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]Dofetilide from recombinant human ERG after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  2.12E+3nMAssay Description:Displacement of [3H]BTCP from recombinant human dopamine transporter after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 min by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451457(CHEMBL4210135)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451458(CHEMBL4205773)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451456(CHEMBL4215058)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451458(CHEMBL4205773)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451454(CHEMBL4207534)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457839(CHEMBL4211921)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457826(CHEMBL4216500)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457833(CHEMBL4210892)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451459(CHEMBL4208664)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451453(CHEMBL2325603)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50503234(CHEMBL4575703)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457837(CHEMBL4215846)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human Nav1.2 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457833(CHEMBL4210892)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457839(CHEMBL4211921)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457827(CHEMBL4203759)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451448(CHEMBL4213464)
Affinity DataIC50: <4nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at unphosphorylated human His-tagged TrkA (441 to 796 residues) expressed in baculovirus expression system preincubated for 20 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457824(CHEMBL4204174)
Affinity DataIC50:  4.20nMAssay Description:Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50503233(CHEMBL4465781)
Affinity DataIC50:  4.70nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451460(CHEMBL4215917)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat Nav1.6 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226350(US9328096, 43)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457828(CHEMBL4218103)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human Nav1.6 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at unphosphorylated rat TrkA expressed in baculovirus expression system preincubated for 20 mins followed by TK-substrate-Biotin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457837(CHEMBL4215846)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataIC50:  6.20nMAssay Description:Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457829(CHEMBL4208510)
Affinity DataIC50:  6.60nMAssay Description:Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457837(CHEMBL4215846)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457839(CHEMBL4211921)
Affinity DataIC50:  7.70nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457836(CHEMBL4213038)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457829(CHEMBL4208510)
Affinity DataIC50:  8.40nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataIC50:  8.40nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451455(CHEMBL2325325)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451452(CHEMBL2321912)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457824(CHEMBL4204174)
Affinity DataIC50:  8.70nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226502(US9328096, 195)
Affinity DataIC50:  9.90nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451450(CHEMBL4208535)
Affinity DataIC50: <10nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM226354(US9328096, 47)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457823(CHEMBL4204070)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457840(CHEMBL4216371)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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