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Found 2627 with Last Name = 'fu' and Initial = 'w'
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408679(CHEMBL5287792)
Affinity DataKi:  0.00260nMAssay Description:Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408509(CHEMBL5277326)
Affinity DataKi:  0.00340nMAssay Description:Antagonist activity at AT1 receptor in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50577958(CHEMBL4859512)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50598866(CHEMBL5205530)
Affinity DataKi:  0.0240nMAssay Description:Displacement of [3H]DAMGO from rat MOR expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50598866(CHEMBL5205530)
Affinity DataKi:  0.0510nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50577958(CHEMBL4859512)
Affinity DataKi:  0.0720nMAssay Description:Displacement of [3H]DPDPE from rat delta opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  0.170nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408675(CHEMBL5270915)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentrati...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50577958(CHEMBL4859512)
Affinity DataKi:  0.294nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463297(CHEMBL4246433)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463294(CHEMBL4249256)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50506108(CHEMBL4449252)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membrane measured after 30 mins by liquid scintillation counting m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50506108(CHEMBL4449252)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes incubated for 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Ovis aries)
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222885(6-(4-fluorophenoxy)-3-[(1-isopropylpiperidin-3-yl)...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Fudan University

LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.480nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Fudan University

LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]-spiperone from dopamine D3 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463297(CHEMBL4246433)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408677(CHEMBL5274117)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.740nMAssay Description:Antagonist activity at D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM248056(1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluo...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in CHO cell membrane measured after 60 mins by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Ovis aries)
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222867((S)-6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3...)
Affinity DataKi:  0.860nMAssay Description:Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Ovis aries)
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222875(6-(4-fluorophenoxy)-2-(2-methylphenyl)-3-(piperidi...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Ovis aries)
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222867((S)-6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM21130(N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...)
Affinity DataKi:  0.900nMAssay Description:Antagonist activity at oxytocin receptor in Wistar rat uterus assessed as inhibition of oxytocin-induced uterotonic activity treated 1 min prior to o...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  0.910nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  1.08nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-spiperone from dopamine D2 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50551170(CHEMBL4786173)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408676(CHEMBL5272258)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408673(CHEMBL5275873)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentrati...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Fudan University

LigandPNGBDBM86180(CAS_87075-17-0 | NSC_5018 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  1.69nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Ovis aries)
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222859(6-(4-chlorophenyl)-3-{[(3S)-1-ethylpiperidin-3-yl]...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Fudan University

LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408816(CHEMBL5279890)
Affinity DataKi:  1.80nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractionsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGrowth hormone secretagogue receptor type 1(Ovis aries)
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222884(6-(4-chlorophenyl)-3-[(-1-ethylpiperidin-3-yl)meth...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Ovis aries)
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50222873(6-(4-chlorophenyl)-3-[(1-isopropylpiperidin-3-yl)m...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]ghrelin from ovine recombinant GHSR1a expressed in HEK293F cells after 6 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50403163(OXITRIPTAN)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408813(CHEMBL5273356)
Affinity DataKi:  2nMAssay Description:Antagonist activity at MTL receptor in rabbit duodenum homogenateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50463293(CHEMBL4242847)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50408514(CHEMBL5281561)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentrati...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Fudan University

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  2.30nMAssay Description:Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM21008((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataKi:  2.30nMAssay Description:Antagonist activity at human recombinant EP1 receptor expressed in CHO cells assessed as luciferase activity by Schild assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
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