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Found 51 with Last Name = 'gatuz' and Initial = 'jl'
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKi:  7.60E+3nM IC50:  6.20E+3nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKi:  1.11E+4nMAssay Description:Mixed-type inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate assessed as enzyme-substrate-inhibitor co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKi:  1.11E+4nMAssay Description:Mixed-type inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate assessed as enzyme-inhibitor complex by D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKi:  1.15E+4nM IC50:  1.09E+4nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM47844(4-chloranyl-N-(1-methylbenzimidazol-5-yl)benzamide...)
Affinity DataKi:  2.75E+4nMAssay Description:Competitive inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495206(CHEMBL3105073)
Affinity DataIC50:  160nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataIC50:  230nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495212(CHEMBL1876821)
Affinity DataIC50:  940nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50:  980nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM31530(2-methyl-5-[(methylamino)methyl]-N-[(1R)-1-(naphth...)
Affinity DataIC50:  1.18E+3nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50:  1.20E+3nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM154574(N-(2H-1,3-benzodioxol-5-ylmethyl)-1-[(1S)-1-(napht...)
Affinity DataIC50:  2.26E+3nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495206(CHEMBL3105073)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495205(CHEMBL3105074)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495204(CHEMBL1478361)
Affinity DataIC50:  1.61E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495214(ALEXIDINE DIHYDROCHLORIDE | Alexidine.Dihydrochlor...)
Affinity DataIC50:  1.78E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM47844(4-chloranyl-N-(1-methylbenzimidazol-5-yl)benzamide...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataIC50:  2.04E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495214(ALEXIDINE DIHYDROCHLORIDE | Alexidine.Dihydrochlor...)
Affinity DataIC50:  2.45E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495205(CHEMBL3105074)
Affinity DataIC50:  2.45E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495214(ALEXIDINE DIHYDROCHLORIDE | Alexidine.Dihydrochlor...)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495210(CHEMBL1488602)
Affinity DataIC50:  2.56E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM47844(4-chloranyl-N-(1-methylbenzimidazol-5-yl)benzamide...)
Affinity DataIC50:  2.76E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495211(CHEMBL3105075)
Affinity DataIC50:  2.83E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495203(CHEMBL1906723)
Affinity DataIC50:  2.88E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495207(CHEMBL3105072)
Affinity DataIC50:  2.98E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495211(CHEMBL3105075)
Affinity DataIC50:  2.98E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495213(CHEMBL3105071)
Affinity DataIC50:  2.99E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM47844(4-chloranyl-N-(1-methylbenzimidazol-5-yl)benzamide...)
Affinity DataIC50:  3.09E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495203(CHEMBL1906723)
Affinity DataIC50:  4.09E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495204(CHEMBL1478361)
Affinity DataIC50:  6.19E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495209(CHEMBL1732790)
Affinity DataIC50:  7.45E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495208(CHEMBL1392147)
Affinity DataIC50:  7.67E+4nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotase(Bacillus anthracis (Firmicute))
University of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C Virus (Virus))
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C Virus (Virus))
University of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotase(Bacillus anthracis (Firmicute))
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495210(CHEMBL1488602)
Affinity DataIC50:  1.86E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495213(CHEMBL3105071)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495212(CHEMBL1876821)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495209(CHEMBL1732790)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495208(CHEMBL1392147)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50495207(CHEMBL3105072)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKd:  2.13E+4nMAssay Description:Binding affinity to SARS coronavirus 3C-like protease using 5-FAM-TSATLQSGFRK(QXL520)-NH2 as substrate by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKd:  1.84E+4nMpH: 7.4Assay Description:Each PLpro enzyme was immobilized on a CM5 sensor chip using standard aminecoupling with running buffer HBS-P (10 mM HEPES, 150 mM NaCl, 0.05% surfac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University of Illinois At Chicago

LigandPNGBDBM154575(3-chloro-N-[5-(7-ethoxy-1-benzofuran-2-yl)-1,3,4-o...)
Affinity DataKd:  3.99E+4nMpH: 7.4Assay Description:Each PLpro enzyme was immobilized on a CM5 sensor chip using standard aminecoupling with running buffer HBS-P (10 mM HEPES, 150 mM NaCl, 0.05% surfac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM154573(8-(trifluoromethyl)-9H-purin-6-amine (4) | acs.jme...)
Affinity DataKd:  2.63E+4nMpH: 7.4Assay Description:Each PLpro enzyme was immobilized on a CM5 sensor chip using standard aminecoupling with running buffer HBS-P (10 mM HEPES, 150 mM NaCl, 0.05% surfac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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