TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.180nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.630nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 1.32nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 1.46nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 1.54nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 3.11nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 3.70nMAssay Description:Compound was evaluated for its invitro competition binding studies using sigma-ligand (0.05-10000 nM) - [3H]-(+)-pentazocine (sigma1 receptor) in gui...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 4.30nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 4.97nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 6.65nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 10.1nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 27.7nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 41.8nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 0.00130nMAssay Description:Inhibition of beta2 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.00300nMAssay Description:Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in h...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00300nMAssay Description:Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in h...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00300nMAssay Description:Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in h...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0180nMAssay Description:Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0220nMAssay Description:Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in h...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0340nMAssay Description:Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0450nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 0.0580nMAssay Description:Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Binding affinity to beta2 adrenoceptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding affinity to beta2 adrenoceptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Binding affinity to serotonin transporterMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Binding affinity to human parathyroid calcium receptor 1 expressed in HEK293 4.0-7 cells by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of beta2 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in h...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of beta2 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Binding affinity to serotonin transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Binding affinity to beta2 adrenoceptorMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Binding affinity to beta2 adrenoceptorMore data for this Ligand-Target Pair