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Found 333 with Last Name = 'ge' and Initial = 'hm'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))TBA
LigandPNGBDBM50436682(CHEMBL2396674)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to human recombinant his-tagged MDM2 assessed as inhibition constant by fluorescence polarization based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191983(3-((1-((R)-1-amino-1-oxo-3-phenylpropan-2-ylamino)...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191983(3-((1-((R)-1-amino-1-oxo-3-phenylpropan-2-ylamino)...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  10nMAssay Description:Compound was evaluated for in vitro binding affinity towards Dopamine receptor D2 in rat striatum using [3H]- spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191986((2R)-2-(2-(5-fluoro-1H-indole-2-carboxamido)-4-mer...)
Affinity DataKi:  12nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002107(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated for in vitro binding affinity towards serotonin 5-hydroxytryptamine 2 receptor in rat cortex using [3H]- spiperone as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191996(6-((1-((R)-1-amino-1-oxo-3-phenylpropan-2-ylamino)...)
Affinity DataKi:  26nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002107(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataKi:  40nMAssay Description:Compound was evaluated for in vitro binding affinity towards serotonin 5-hydroxytryptamine 1A receptor receptor in rat hippocampus using [3H]-8-OH-D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  50nMAssay Description:Compound was evaluated for in vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat cortex using [3H]- spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  60nMAssay Description:Compound was evaluated for in vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat cortex using [3H]- spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191987(6-((1-((R)-1-carboxy-2-phenylethylamino)-4-mercapt...)
Affinity DataKi:  120nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191987(6-((1-((R)-1-carboxy-2-phenylethylamino)-4-mercapt...)
Affinity DataKi:  120nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191983(3-((1-((R)-1-amino-1-oxo-3-phenylpropan-2-ylamino)...)
Affinity DataKi:  130nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50192000(3-((1-((R)-1-carboxy-2-phenylethylamino)-4-mercapt...)
Affinity DataKi:  140nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191991((2R)-2-(4-mercapto-2-(7-nitro-1H-indole-2-carboxam...)
Affinity DataKi:  150nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191982((2R)-2-(4-mercapto-2-(2-(2-nitrophenyl)furan-5-car...)
Affinity DataKi:  160nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50192002((2R)-2-(2-(4-(benzyloxy)-3,5-dimethylbenzamido)-4-...)
Affinity DataKi:  200nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191992((2R)-2-(2-(5-chloro-1H-indole-2-carboxamido)-4-mer...)
Affinity DataKi:  200nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191998((2R)-2-(2-(3-butylpicolinamido)-4-mercaptobutanami...)
Affinity DataKi:  230nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50192003((2R)-2-(2-(3-chloro-2-hydroxynicotinamido)-4-merca...)
Affinity DataKi:  260nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191997((2R)-2-(2-(1H-indole-2-carboxamido)-4-mercaptobuta...)
Affinity DataKi:  290nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191989((2R)-2-(4-mercapto-2-(2-(naphthalen-1-yloxy)acetam...)
Affinity DataKi:  290nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191984((2R)-2-(2-(2-(4-bromophenyl)acetamido)-4-mercaptob...)
Affinity DataKi:  350nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50192001((2R)-2-(2-(2-(4-acetamido-3-nitrophenyl)acetamido)...)
Affinity DataKi:  390nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002107(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataKi:  520nMAssay Description:Compound was evaluated for in vitro binding affinity towards Dopamine receptor D2 in rat striatum using [3H]- spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191985((2R)-2-(4-mercapto-2-(3-(trimethylsilyl)propanamid...)
Affinity DataKi:  520nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191988((2R)-2-(2-(4-hydroxy-3,5-dimethylbenzamido)-4-merc...)
Affinity DataKi:  540nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191994((2R)-2-(2-(5-hydroxy-1H-indole-2-carboxamido)-4-me...)
Affinity DataKi:  570nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  640nMAssay Description:Compound was evaluated for in vitro binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191993((2R)-2-(2-(3-cyclohexylpropanamido)-4-mercaptobuta...)
Affinity DataKi:  780nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191995((2R)-2-(2-(2-(2-chloro-5-nitrophenyl)acetamido)-4-...)
Affinity DataKi:  780nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  790nMAssay Description:Compound was evaluated for in vitro binding affinity towards Dopamine receptor D2 in rat striatum using [3H]- spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50192004((2R)-2-(2-(3-butylpicolinamido)-3-mercaptopropanam...)
Affinity DataKi:  880nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191990((2R)-2-(4-mercapto-2-(2-(3-nitrophenyl)acetamido)b...)
Affinity DataKi:  1.03E+3nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002107(3-{4-[4-(6-Fluoro-benzo[b]thiophen-3-yl)-piperazin...)
Affinity DataKi:  2.74E+3nMAssay Description:Compound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50191999((2R)-2-(2-(2-(4-bromophenyl)acetamido)-3-mercaptop...)
Affinity DataKi:  3.67E+3nMAssay Description:Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5.75E+3nMAssay Description:Compound was evaluated for in vitro binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50269378(CHEMBL447311 | apigenin-4'-O-(2''-O-p-coumaroyl)-b...)
Affinity DataKi:  1.44E+4nMAssay Description:Inhibition of xanthine oxidase (unknown origin) by competitive Lineweaver-burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367064(CHEMBL1204338)
Affinity DataIC50: >1nMAssay Description:Compound was tested in vitro for inhibition of rat brain mitochondrial monoamine oxidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367064(CHEMBL1204338)
Affinity DataIC50: >1nMAssay Description:Compound was tested in vitro for inhibition of rat brain mitochondrial monoamine oxidase A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL
LigandPNGBDBM50508562(CHEMBL4541928)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetThromboxane A2 receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50075643((E)-6-[3-(1-tert-Butylamino-2,2-dicyano-vinylamino...)
Affinity DataIC50:  3nMAssay Description:In vitro activity on thromboxane A2 receptor antagonism in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50075637(6-{3-[2-cyano-1-isopentylamino-(E)-1-iminomethylam...)
Affinity DataIC50:  3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50075645(6-{3-[2-cyano-1-cyclohexylamino-(E)-1-iminomethyla...)
Affinity DataIC50:  3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50075630(6-{3-[1-(1-adamantylamino)-2-cyano-(E)-1-iminometh...)
Affinity DataIC50:  3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50075644((E)-6-[3-({[(E)-Benzenesulfonylimino]-tert-butylam...)
Affinity DataIC50:  3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50075618(6-{3-[2-cyano-1-cyclopentylamino-(E)-1-iminomethyl...)
Affinity DataIC50:  3nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50607976(CHEMBL5271815)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine chloride as substrate incubated for 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50003795(5-[1-Pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-met...)
Affinity DataIC50:  4nMAssay Description:In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Homo sapiens (Human))
Selvita

Curated by ChEMBL
LigandPNGBDBM50508559(CHEMBL4592338)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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