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Found 68 with Last Name = 'gesner' and Initial = 'tg'
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185219((S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinu...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185221((S)-3-(1H-benzo[d]imidazol-2-yl)-6-methyl-4-(quinu...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185218((S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(pyrro...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380230(CHEMBL2016862)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380229(CHEMBL2016996)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380236(CHEMBL2016856)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185217(3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(piperidin...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185224(3-(1H-benzo[d]imidazol-2-yl)-6-methyl-4-(piperidin...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272192(4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186356(2-(5-(benzyloxy)-6-methoxy-1H-indazol-3-yl)-5-(4-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185220(3-(1H-benzo[d]imidazol-2-yl)-6-methyl-4-(piperidin...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185216(3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(piperidin...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272242(6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272244(6-(3-(benzyloxy)phenyl)-4-(1H-indazol-5-yl)pyrimid...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186360(CHEMBL209753 | N-(1-benzylpiperidin-4-yl)-3-(5-(4-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185226((R)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(pyrro...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185215((S)-3-(1H-benzo[d]imidazol-2-yl)-4-(quinuclidin-3-...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380225(CHEMBL2017000)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380234(CHEMBL2016858)
Affinity DataIC50:  9nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272240(6-(2-fluorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186362(3-(5-(4-(piperidin-1-yl)piperidin-1-yl)-1H-benzo[d...)
Affinity DataIC50:  10nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272193(4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one | ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186357(2-(5-(2-methoxyphenoxy)-1H-indazol-3-yl)-5-(4-(pip...)
Affinity DataIC50:  20nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185223((S)-3-(1H-benzo[d]imidazol-2-yl)-5,6-dichloro-4-(q...)
Affinity DataIC50:  22nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272191(4-(4-hydroxyphenyl)-6-phenylpyrimidin-2(1H)-one | ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185169(2-(5-phenoxy-1H-indazol-3-yl)-5-(4-(piperidin-1-yl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185178(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380235(CHEMBL2016857)
Affinity DataIC50:  33nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380233(CHEMBL2016859)
Affinity DataIC50:  33nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272284(4-(1H-indazol-5-yl)-6-(4-(piperazin-1-yl)phenyl)py...)
Affinity DataIC50:  40nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380226(CHEMBL2016999)
Affinity DataIC50:  41nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185182(2-(5-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186361(CHEMBL211154 | N-(furan-2-ylmethyl)-3-(5-(4-(piper...)
Affinity DataIC50:  60nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186355(2-(5-(3-methoxyphenoxy)-1H-indazol-3-yl)-5-(4-(pip...)
Affinity DataIC50:  60nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272283(6-(4-ethylphenyl)-4-(1H-indazol-5-yl)pyrimidin-2(1...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272243(4-(1H-indazol-5-yl)-6-(3-(trifluoromethyl)phenyl)p...)
Affinity DataIC50:  110nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186364(CHEMBL384213 | N-benzyl-3-(5-(4-(piperidin-1-yl)pi...)
Affinity DataIC50:  130nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185214((S)-3-(1H-benzo[d]imidazol-2-yl)-8-methyl-4-(quinu...)
Affinity DataIC50:  138nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186358(CHEMBL377463 | N-(3-(5-(4-(piperidin-1-yl)piperidi...)
Affinity DataIC50:  150nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272241(6-(3-fluorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(...)
Affinity DataIC50:  150nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185184(2-(6-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186363(2-(5-(4-methoxyphenoxy)-1H-indazol-3-yl)-5-(4-(pip...)
Affinity DataIC50:  220nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186359(2-(5-methoxy-1H-indazol-3-yl)-5-(4-(piperidin-1-yl...)
Affinity DataIC50:  230nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272282(6-(4-(benzyloxy)phenyl)-4-(1H-indazol-5-yl)pyrimid...)
Affinity DataIC50:  350nMAssay Description:Inhibition of CDC7-DBF4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380232(CHEMBL2016860)
Affinity DataIC50:  370nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  430nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185222((R)-3-(1H-benzo[d]imidazol-2-yl)-4-(quinuclidin-3-...)
Affinity DataIC50:  482nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185170(2-(1H-indazol-3-yl)-5-(4-(piperidin-1-yl)piperidin...)
Affinity DataIC50:  600nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181305(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Affinity DataIC50:  731nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50186365(2-(5,6-bis(benzyloxy)-1H-indazol-3-yl)-5-(4-(piper...)
Affinity DataIC50:  900nMAssay Description:Inhibition of c-ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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