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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50185222
Substrate
n/a
Meas. Tech.
ChEMBL_359757 (CHEMBL871263)
IC50
482±n/a nM
Citation
 Ni, ZJ; Barsanti, P; Brammeier, N; Diebes, A; Poon, DJ; Ng, S; Pecchi, S; Pfister, K; Renhowe, PA; Ramurthy, S; Wagman, AS; Bussiere, DE; Le, V; Zhou, Y; Jansen, JM; Ma, S; Gesner, TG 4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors. Bioorg Med Chem Lett 16:3121-4 (2006) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50185222
Synonyms:
(R)-3-(1H-benzo[d]imidazol-2-yl)-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one | CHEMBL208937
Type:
Small organic molecule
Emp. Form.:
C23H23N5O
Mol. Mass.:
385.4616
SMILES:
O=c1[nH]c2ccccc2c(N[C@H]2CN3CCC2CC3)c1-c1nc2ccccc2[nH]1 |wD:11.11,TLB:10:11:15.14:17.18,(10.4,-12.01,;9.07,-11.25,;7.73,-12.02,;6.39,-11.26,;5.05,-12.02,;3.72,-11.25,;3.72,-9.71,;5.05,-8.94,;6.38,-9.7,;7.71,-8.92,;7.71,-7.38,;6.76,-6.17,;6.48,-4.78,;5.13,-4.17,;3.67,-4.81,;3.86,-6.19,;5.39,-5.54,;5.65,-3.64,;5.2,-2.54,;9.06,-9.69,;10.39,-8.92,;11.8,-9.55,;12.82,-8.41,;14.36,-8.41,;15.13,-7.07,;14.35,-5.73,;12.81,-5.74,;12.05,-7.07,;10.54,-7.4,)|
Structure:
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