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Found 1617 with Last Name = 'guo' and Initial = 'b'
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620037((3S,8aR*)-3-(5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-...)
Affinity DataIC50:  0.100nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619989((3S)-3-(5-(3-Amino-1H-indazol-6-yl)-1H-imidazol-2-...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619887(5-(5-Chloro-2-((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619914(5-(2-((3*S,8aR)-7-(3-Chloro-2-fluoro-6-(1H-tetrazo...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619925(N-(4-(2-((3S,8a*R)-7-(3-Chloro-2-fluoro-6-(1H-tetr...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619926(N-(4-(24(3S,8aS*)-7-(3-choro-2-fluoro-6-(1H-tetraz...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620045(N-(4-(2-((3S)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619953(6-(2-((3S,8aR)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620017(Methyl (4-(2-((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620029((3S,8aR)-3-(5-(6-Amino-2-chloropyridin-3-yl)-1H-im...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620030(Methyl (4-(2-((3S)-7-(3-chloro-2-fluoro-6-(1H-tetr...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620044(N-(2-(2-((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetra...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619946(US20230295157, Example 270)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetEstrogen receptor beta(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at ERbeta expressed in HEK293/Gal4 cells incubated for 24 hrs in presence of di-arylpropionitrile by luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619761(US20230295157, Example 84)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
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TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619934((3S)-7-[3-Chloro-2-fluoro-6-(tetrazol-1-yl)phenyl]...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619937(US20230295157, Example 261)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619957(6-(2-((3S,8aR)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619968(5-(2-((3S,8aS)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619973(6-(2-((3S)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-y...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619983(N-(2-(2-((3S,8aR)-7-(3-Chloro-2-fluoro-6-(1H-tetra...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619987(6-(2-((3S)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-y...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619988(5-(2-((3S)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-y...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620016(Methyl (4-(2-((3S,8aS)-7-(3-chloro-2-fluoro-6-(1H-...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620027((3S,8aS)-3-(5-(6-Amino-2-chloropyridin-3-yl)-1H-im...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619805((3S,8aR)-3-(5-(6-amino-2-fluoropyridin-3-yl)-1H-im...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620047((3S,8aR)-3-(5-(2-aminopyridin-4-yl)-4-chloro-1H-im...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619747(US20230295157, Example 69)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619748(US20230295157, Example 70)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619894(4-(5-Chloro-2-((3S)-7-(3-chloro-2-fluoro-6-(1H-tet...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619830((3S,8aR)-3-[5-(6-amino-2-fluoro-3-pyridyl)-4-deute...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619810((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619858(4-(2-((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetrazol...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619869(US20230295157, Example 193)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619906((3S,8aR)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619925(N-(4-(2-((3S,8a*R)-7-(3-Chloro-2-fluoro-6-(1H-tetr...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619941(US20230295157, Example 265)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619946(US20230295157, Example 270)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620042(N-(4-(2-((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetra...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620063((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619794(6-(24(3*S,8a*R)-7-(3-chloro-2-fluoro-6-(1H-tetrazo...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619796((3*S,8aR)-3-(5-(6-amino-2-fluoropyridin-3-yl-5-d)-...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619796((3*S,8aR)-3-(5-(6-amino-2-fluoropyridin-3-yl-5-d)-...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619805((3S,8aR)-3-(5-(6-amino-2-fluoropyridin-3-yl)-1H-im...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619805((3S,8aR)-3-(5-(6-amino-2-fluoropyridin-3-yl)-1H-im...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619854((3R,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)...)
Affinity DataIC50:  0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620005(N-(2-(2-((3S)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol-...)
Affinity DataIC50:  0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619805((3S,8aR)-3-(5-(6-amino-2-fluoropyridin-3-yl)-1H-im...)
Affinity DataIC50:  0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619837((3S)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phen...)
Affinity DataIC50:  0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619855((3R,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)...)
Affinity DataIC50:  0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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