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Found 1336 with Last Name = 'kawai' and Initial = 'h'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090488(1-Benzyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  640nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D2 by displacing the radioligand [3H]-YM-09151-2 (0.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50017041((RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline | 1,2...)
Affinity DataKi:  3.57E+3nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D2 by displacing the radioligand [3H]-YM-09151-2 (0.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090489(4-(1,2,3,4-Tetrahydro-isoquinolin-1-ylmethyl)-benz...)
Affinity DataKi:  8.79E+3nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D2 by displacing the radioligand [3H]-YM-09151-2 (0.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090488(1-Benzyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  9.27E+3nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]-SCH-23,390 (1.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090489(4-(1,2,3,4-Tetrahydro-isoquinolin-1-ylmethyl)-benz...)
Affinity DataKi:  2.15E+4nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine transporter by displacing the radioligand [3H]-GBR-12,935 (1.0 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50017041((RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline | 1,2...)
Affinity DataKi:  3.66E+4nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine transporter by displacing the radioligand [3H]-GBR-12,935 (1.0 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090488(1-Benzyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  5.76E+4nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine transporter by displacing the radioligand [3H]-GBR-12,935 (1.0 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50090489(4-(1,2,3,4-Tetrahydro-isoquinolin-1-ylmethyl)-benz...)
Affinity DataKi:  1.75E+5nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]-SCH-23,390 (1.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50017041((RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline | 1,2...)
Affinity DataKi:  2.49E+5nMAssay Description:The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]-SCH-23,390 (1.5 nM) in rat s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635953((1R,2S)-2-(3-((5-chloro-6-(1,1-dioxidothiomorpholi...)
Affinity DataIC50:  0.350nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635903((1R,2S)-2-(3-{[(3S)-3-hydroxy-2,3-dihydro-1-benzof...)
Affinity DataIC50:  0.375nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProgesterone receptor(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at human PR expressed in CHO-K1 cells assessed as reduction in progesterone-induced response incubated for 20 hrs by luciferase r...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635951((1R,2S)-2-(3-{[5-chloro-2-cyclopropyl-6-(3-hydroxy...)
Affinity DataIC50:  0.434nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50:  0.496nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636141(5-methoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.564nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636146(5-ethoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-di...)
Affinity DataIC50:  0.590nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276045((R)-3-Amino-4-(5-chloro-2-fluoro-phenyl)-N-{4-[6-(...)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636127((1R,2S)-5'-methoxy-2-(3-{[3-methoxy-5-(8-oxa-3-aza...)
Affinity DataIC50:  0.650nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636134((1R,2S)-2-(3-{[5-(azetidine-1-carbonyl)-3-methoxyp...)
Affinity DataIC50:  0.650nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635884((1R,2S)-2-(3-{[5-chloro-6-(morpholin-4-yl)pyrimidi...)
Affinity DataIC50:  0.694nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636070((1R,2S)-5'-methoxy-2-{3-[2-methoxy-4-(morpholine-4...)
Affinity DataIC50:  0.716nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636116((1R,2S)-2-[3-({6-[(2R,6S)-2,6-dimethylpiperidine-1...)
Affinity DataIC50:  0.738nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636145((1R,2S)-2-(3-{[5-(ethanesulfonyl)-3-ethoxypyridin-...)
Affinity DataIC50:  0.763nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636135((1R,2S)-5'-methoxy-2-(3-{[3-methoxy-5-(morpholine-...)
Affinity DataIC50:  0.785nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276047((R)-3-Amino-N-{4-[6-(2-morpholin-4-yl-ethoxy)-benz...)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636037(6-methoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.802nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636149((1R,2S)-2-(3-{[6-(2-hydroxypropan-2-yl)-3-methoxyp...)
Affinity DataIC50:  0.804nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636077(2-fluoro-5-methoxy-4-({6-[(1R,2S)-5'-methoxy-2'-ox...)
Affinity DataIC50:  0.806nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636075(5-methoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.810nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635997((1R,2S)-5'-methoxy-2-(3-{[5-methoxy-2-(propan-2-yl...)
Affinity DataIC50:  0.833nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636143((1R,2S)-2-{3-[2-ethoxy-4-(methanesulfonyl)anilino]...)
Affinity DataIC50:  0.833nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636117((1R,2S)-5'-methoxy-2-(3-{[2-methoxy-6-(8-oxa-3-aza...)
Affinity DataIC50:  0.843nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636139((1R,2S)-2-(3-{[5-(azetidine-1-sulfonyl)-3-methoxyp...)
Affinity DataIC50:  0.874nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636140(5-methoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.890nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636079((1R,2S)-2-{3-[5-fluoro-2-methoxy-4-(morpholine-4-c...)
Affinity DataIC50:  0.897nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636078((1R,2S)-2-{3-[5-fluoro-2-methoxy-4-(morpholine-4-c...)
Affinity DataIC50:  0.952nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636089(N,6-dimethoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',...)
Affinity DataIC50:  0.955nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636065(6-methoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.965nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636130((1R,2S)-5'-methoxy-2-(3-{[3-methoxy-5-(oxane-4-sul...)
Affinity DataIC50:  0.971nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636026((1R,2S)-5'-methoxy-2-(3-{[5-methoxy-2-(oxan-4-yl)p...)
Affinity DataIC50:  0.976nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636040((1R,2S)-2-[3-({2-[(3R)-3-fluoropyrrolidin-1-yl]-5-...)
Affinity DataIC50:  0.995nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635947((1R,2S)-2-(3-{[5-chloro-6-(3-hydroxyazetidin-1-yl)...)
Affinity DataIC50:  0.997nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276001((R)-3-Amino-N-{4-[6-(2-methoxy-ethoxy)-benzothiazo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636085(6-ethoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-di...)
Affinity DataIC50:  1.01nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636027((1R,2S)-5'-methoxy-2-(3-{[5-methoxy-2-(methylsulfa...)
Affinity DataIC50:  1.03nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636103((1R,2S)-5'-methoxy-2-(3-{[2-methoxy-6-(3-oxa-8-aza...)
Affinity DataIC50:  1.03nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636060((1R,2S)-2-(3-{[2-(4,4-difluoropiperidin-1-yl)-5-me...)
Affinity DataIC50:  1.04nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636074(5-ethoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-di...)
Affinity DataIC50:  1.04nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636068(5-methoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  1.08nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635945((1R,2S)-2-(3-((5-chloro-2-cyclopropyl-6-(1,1-dioxi...)
Affinity DataIC50:  1.10nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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