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Found 7219 with Last Name = 'kehler' and Initial = 'j'
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50318633(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50019704(CHEMBL3286578)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]raclopride from human dopamine D2L receptor expressed in CHOK1a cell membrane after 180 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50056445(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)
Affinity DataKi:  0.660nMAssay Description:Displacement of [125]iodosulpride from human recombinant dopamine D2L receptor expressed in CHO cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50019711(CHEMBL3286585)
Affinity DataKi:  0.75nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50019754(IDALOPIRDINE | LU-AE58054)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337403(CHEMBL1682668 | methyl 1-(((1R,2S)-2-(benzyl(methy...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337411((1S,2R)-1-(3,4-dichlorophenyl)-N-(4-fluorobenzyl)-...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50024204(1H-imidazo[4,5-c]pyridine derivative | 2N-[4,7-dim...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]5-HT from human recombinant 5-HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337418((1S,2R)-1-(3,4-dichlorophenyl)-2-((3-(4-(N,N-dimet...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50241119(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]nemonapride from dopamine D2L receptor (unknown origin) expressed in African green monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337404((1S,2R)-N-benzyl-1-(3,4-dichlorophenyl)-2-((4-(3,3...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337409((1S,2R)-1-(3,4-dichlorophenyl)-N-(4-fluorobenzyl)-...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337407(CHEMBL1682672 | N1-(1-(((1R,2S)-2-(benzyl(methyl)c...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337410((1S,2R)-1-(3,4-dichlorophenyl)-N-(4-fluorobenzyl)-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337401((1S,2R)-N-benzyl-1-(3,4-dichlorophenyl)-N-methyl-2...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337435(CHEMBL1682637 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337425(CHEMBL1682628 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337405((1S,2R)-N-benzyl-1-(3,4-dichlorophenyl)-N-methyl-2...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337431((1S,2R)-2-((4-acetamido-4-phenylpiperidin-1-yl)met...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337416((1S,2R)-1-(3,4-dichlorophenyl)-N-(4-fluorobenzyl)-...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337421((1S,2R)-2-((4-acetamido-4-phenylpiperidin-1-yl)met...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337441(CHEMBL1682643 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337402((1S,2R)-N-benzyl-1-(3,4-dichlorophenyl)-N-methyl-2...)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337413((1S,2R)-1-(3,4-dichlorophenyl)-N-(4-fluorobenzyl)-...)
Affinity DataKi:  7.30nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337397((1S,2R)-2-((4-acetamido-4-phenylpiperidin-1-yl)met...)
Affinity DataKi:  7.30nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337433(CHEMBL1681797 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337415((1S,2R)-1-(3,4-dichlorophenyl)-2-((4-(N,N-dimethyl...)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337408((1S,2R)-N-benzyl-1-(3,4-dichlorophenyl)-N-methyl-2...)
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50370912(CHEMBL1202309)
Affinity DataKi:  8nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-3-gamma-2S expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337417((1S,2R)-2-((4-(2-(azepan-1-yl)acetyl)piperazin-1-y...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50370916(CHEMBL1202310)
Affinity DataKi:  9nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-3-gamma-2S expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50019706(CHEMBL3286581)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50208721(4-(biphenyl-3-yl)-5-(piperidin-4-yl)isoxazol-3-ol ...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-3-gamma-2S expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337432(CHEMBL1682635 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50090524(4-Amino-N-(2,6-bis-methylamino-pyridin-4-yl)-benze...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337427(CHEMBL1682630 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337414((1S,2R)-1-(3,4-dichlorophenyl)-N-(4-fluorobenzyl)-...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337406((1S,2R)-N-benzyl-1-(3,4-dichlorophenyl)-N-methyl-2...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337439(CHEMBL1682641 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337426(CHEMBL1682629 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337445(CHEMBL1682647 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM81993(BROMOCRIPTINE | Bromocriptine+ (GTP+) | Bromocript...)
Affinity DataKi:  15nMAssay Description:Displacement of [125]iodosulpride from human recombinant dopamine D2L receptor expressed in CHO cells after 30 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNeuromedin-K receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50337434(CHEMBL1682636 | rac-2-((4-acetamido-4-phenylpiperi...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]Lu AE93103 from human NK3 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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