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Found 103 with Last Name = 'kilburn' and Initial = 'r'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179771(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataKi:  327nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179768(3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-[4-(...)
Affinity DataKi:  364nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179773(2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-a...)
Affinity DataKi:  787nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179772(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataKi:  798nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179770(3-(3,5-bis-trifluoromethyl-phenyl)-3-hydroxy-1-[4-...)
Affinity DataKi:  862nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179769(3-(3,5-bis-trifluoromethyl-phenyl)-3-methoxy-1-[4-...)
Affinity DataKi:  947nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179777(3-(3,5-bis(trifluoromethyl)phenyl)-1-((1r,4r)-4-(d...)
Affinity DataKi:  984nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137257(1-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataKi:  1.90E+3nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179778(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-3...)
Affinity DataKi:  1.95E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179774(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137261(CHEMBL25211 | N-[4-((S)-1-Amino-2-oxo-2-thiazolidi...)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179775(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-3...)
Affinity DataKi:  2.99E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179779(2-(3,5-bis(trifluoromethyl)phenyl)-N-((1r,4r)-4-(3...)
Affinity DataKi:  3.71E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137271(CHEMBL23979 | N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin...)
Affinity DataKi:  5.70E+3nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137253(CHEMBL22359 | N-[4-((S)-1-Amino-2-oxo-2-thiazolidi...)
Affinity DataKi:  5.90E+3nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179776(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataKi:  6.53E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137272(CHEMBL3084944 | Naphthalene-1-carboxylic acid [4-(...)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137264(CHEMBL3084949 | Naphthalene-1-carboxylic acid [4-(...)
Affinity DataKi:  2.20E+4nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140521(CHEMBL25437 | N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin...)
Affinity DataKi:  3.50E+4nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137260(CHEMBL22679 | [4-((S)-1-Amino-2-oxo-2-pyrrolidin-1...)
Affinity DataKi:  4.00E+4nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50137270(CHEMBL3084938 | N-[4-((S)-1-Amino-2-oxo-2-pyrrolid...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50265158(CHEMBL497992 | N-((trans)-4-((S)-1-amino-2-oxo-2-(...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity for Potassium channel HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179768(3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-[4-(...)
Affinity DataIC50:  0.330nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179773(2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-a...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179778(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-3...)
Affinity DataIC50:  0.480nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179769(3-(3,5-bis-trifluoromethyl-phenyl)-3-methoxy-1-[4-...)
Affinity DataIC50:  0.480nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179775(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-3...)
Affinity DataIC50:  0.480nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179771(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179779(2-(3,5-bis(trifluoromethyl)phenyl)-N-((1r,4r)-4-(3...)
Affinity DataIC50:  0.620nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179770(3-(3,5-bis-trifluoromethyl-phenyl)-3-hydroxy-1-[4-...)
Affinity DataIC50:  0.660nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179772(3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-a...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179774(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179776(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50265158(CHEMBL497992 | N-((trans)-4-((S)-1-amino-2-oxo-2-(...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179777(3-(3,5-bis(trifluoromethyl)phenyl)-1-((1r,4r)-4-(d...)
Affinity DataIC50:  6.20nMAssay Description:Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137259(CHEMBL3084937 | N-[4-((S)-1-Amino-2-oxo-2-thiazoli...)
Affinity DataIC50:  7.5nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137259(CHEMBL3084937 | N-[4-((S)-1-Amino-2-oxo-2-thiazoli...)
Affinity DataIC50:  7.5nMAssay Description:Inhibitory activity against quiescent cell prolyl peptidase (QPP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137248(CHEMBL3084956 | Quinoline-3-carboxylic acid [4-((S...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137248(CHEMBL3084956 | Quinoline-3-carboxylic acid [4-((S...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against quiescent cell prolyl peptidase (QPP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137257(1-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137257(1-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against quiescent cell prolyl peptidase (QPP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137264(CHEMBL3084949 | Naphthalene-1-carboxylic acid [4-(...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against quiescent cell prolyl peptidase (QPP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137264(CHEMBL3084949 | Naphthalene-1-carboxylic acid [4-(...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137262(CHEMBL3084952 | [4-((S)-1-Amino-2-oxo-2-thiazolidi...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137262(CHEMBL3084952 | [4-((S)-1-Amino-2-oxo-2-thiazolidi...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against quiescent cell prolyl peptidase (QPP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137265(1-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against quiescent cell prolyl peptidase (QPP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137265(1-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137244(CHEMBL3084942 | Naphthalene-2-sulfonic acid [4-((S...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137244(CHEMBL3084942 | Naphthalene-2-sulfonic acid [4-((S...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against quiescent cell prolyl peptidase (QPP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50137275(CHEMBL3084948 | Naphthalene-2-carboxylic acid [4-(...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against dipeptidyl-peptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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