Compile Data Set for Download or QSAR
maximum 50k data
Found 141 with Last Name = 'kyne' and Initial = 're'
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]Spiperone from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]Spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataKi:  1.10nMAssay Description:Competitive inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-alpha-methylglucoside uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466891(CHEMBL4281109)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466897(CHEMBL4287715)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466893(CHEMBL4291727)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466892(CHEMBL4283871)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466913(CHEMBL4289304)
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232526(5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-dia...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232538(5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quina...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237216(CHEMBL4080254)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237201(CHEMBL4082618)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237200(CHEMBL4072132)
Affinity DataIC50:  0.0690nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM36530(D157493)
Affinity DataIC50:  0.0800nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237199(CHEMBL4077061)
Affinity DataIC50:  0.110nMAssay Description:In vitro reversal of vecuronium-induced block in isolated guinea pig hemi-diaphragm.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237203(CHEMBL250072)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237205(CHEMBL398675)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237209(CHEMBL4062544)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237211(CHEMBL4061457)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237210(CHEMBL399673)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM36534(D156095)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237217(CHEMBL342595)
Affinity DataIC50:  1nMAssay Description:Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50152828(Apatinib | YN-968D1)
Affinity DataIC50:  1nMAssay Description:Inhibition of VEGF2 receptor (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335784(2-[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methyl-coumarin as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237202(CHEMBL4103454)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237198(CHEMBL4068466)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237218(CHEMBL4072481)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232566(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466890(CHEMBL4290728)
Affinity DataIC50:  3.30nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)
Affinity DataIC50:  4.10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466912(CHEMBL4283051)
Affinity DataIC50:  4.80nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466890(CHEMBL4290728)
Affinity DataIC50:  5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466891(CHEMBL4281109)
Affinity DataIC50:  5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466897(CHEMBL4287715)
Affinity DataIC50:  5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methyl-coumarin as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466893(CHEMBL4291727)
Affinity DataIC50:  5.5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466914(CHEMBL4283312)
Affinity DataIC50:  7.60nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237204(CHEMBL343543)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466915(CHEMBL4282848)
Affinity DataIC50:  7.90nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)
Affinity DataIC50:  9.5nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM189922(US10227346, Example 109 | US10426135, Example 109 ...)
Affinity DataIC50:  10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466908(CHEMBL4283530)
Affinity DataIC50:  10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237206(CHEMBL4075292)
Affinity DataIC50:  11nMAssay Description:In vitro reversal of vecuronium-induced block in isolated guinea pig hemi-diaphragm.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466895(CHEMBL4281170)
Affinity DataIC50:  11nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237212(CHEMBL4100442)
Affinity DataIC50:  12nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466908(CHEMBL4283530)
Affinity DataIC50:  13nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466909(CHEMBL4284588)
Affinity DataIC50:  13nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 141 total ) | Next | Last >>
Jump to: