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Found 2385 with Last Name = 'laird' and Initial = 'er'
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203205((R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203200((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203199((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203211((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203210((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  15.8nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203197((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203206((R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203208((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Affinity DataKi:  62nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203202((R)-N-(4-(piperidin-1-ylmethyl)benzyl)-3-(naphthal...)
Affinity DataKi:  132nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203203((S)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  143nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203207(3-(RS)-N-(4-(piperidin-1-ylmethyl)benzyl)-3-(napht...)
Affinity DataKi:  382nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203204((S)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  1.90E+3nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203198((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  1.33E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203208((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  1.50E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203210((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203197((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203199((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  3.50E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203211((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  4.92E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203200((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi: >5.00E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203207(3-(RS)-N-(4-(piperidin-1-ylmethyl)benzyl)-3-(napht...)
Affinity DataKi:  5.60E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203205((R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-...)
Affinity DataKi:  5.70E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50203198((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((S)-...)
Affinity DataKi:  2.41E+5nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224846(4-(2-{4-[5-(6,8,10-trioxo-1,7,9-triaza-spiro[4.5]d...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224838(1-{6-[4-(6-fluoro-1H-benzoimidazol-2-yl)-phenoxy]-...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224842(1-(6-{4-[4-(3-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224852(1-{6-[4-(6-chloro-1H-benzoimidazol-2-yl)-phenoxy]-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224847(3-(2-{4-[5-(6,8,10-trioxo-1,7,9-triaza-spiro[4.5]d...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224856(1-{6-[4-(1H-benzoimidazol-2-yl)-phenoxy]-pyridin-3...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224837(1-(6-{4-[4-(4-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224857(1-(6-{4-[4-(2-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496941(CHEMBL3236463)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50484212(CHEMBL1822264)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full length B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496943(CHEMBL3236471)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496954(CHEMBL3236470)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496948(CHEMBL3236472)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496946(CHEMBL3236464)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565148(US11414404, Ex. # 25 | US11634409, Example 25)
Affinity DataIC50:  0.340nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194286(5-(2-ethoxyethyl)-5-(4-(4-(4-(pyridin-3-yl)oxazol-...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM565148(US11414404, Ex. # 25 | US11634409, Example 25)
Affinity DataIC50:  0.340nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194306(5-(2-ethoxyethyl)-5-(4-(4-(4-(3-fluorophenyl)oxazo...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194306(5-(2-ethoxyethyl)-5-(4-(4-(4-(3-fluorophenyl)oxazo...)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50485033(CHEMBL2023502)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of full-length B-Raf V600E mutant assessed as reduction in incorporation of radiolabeled phosphate from [gamma-33P]ATP into FSBA-modified ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16384(4-(4-fluorophenyl)-5-[3-(2-methoxyphenyl)-[1,2,4]t...)
Affinity DataIC50:  0.400nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194278(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahydropyri...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16385(5-[3-(2-ethoxyphenyl)-[1,2,4]triazolo[3,4-a]pyridi...)
Affinity DataIC50:  0.400nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224845(5-(2-ethoxyethyl)-5-(4-(4-(6-fluoro-1H-benzo[d]imi...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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