BindingDB PrimarySearch

Tyrosine-protein kinase receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261711(US9708295, 53)

Ki: 3.10nMMore data for this Ligand-Target Pair

Tyrosine-protein kinase receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261689(US9708295, 30)

Ki: 3.20nMMore data for this Ligand-Target Pair

Tyrosine-protein kinase receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261711(US9708295, 53)

Ki: 4.40nMMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50581177(CHEMBL5075032)

Ki: 7nMAssay Description:Binding affinity to PDE9A2 (unknown origin)More data for this Ligand-Target Pair

PC cid PC sid PDB

Details Article PubMed PDB

UniProtKB/SwissProt
GoogleScholar

Acetylcholinesterase(Electrophorus electricus (Electric eel))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50443370(CHEMBL3086276)

Ki: 17nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by ...More data for this Ligand-Target Pair

ALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261689(US9708295, 30)

Ki: 18.8nMMore data for this Ligand-Target Pair

ALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261711(US9708295, 53)

Ki: 32.1nMMore data for this Ligand-Target Pair

ALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261686(US9708295, 27)

Ki: 35.1nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

ALK tyrosine kinase receptor [G1269S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261686(US9708295, 27)

Ki: 61.3nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

ALK tyrosine kinase receptor [G1269S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261689(US9708295, 30)

Ki: 93.3nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

ALK tyrosine kinase receptor [G1269S](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM261711(US9708295, 53)

Ki: 115nMMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Lactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)

Ki: 1.03E+4nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair

Purchase CHEMBL PC cid PC sid PDB Patents Similars

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Lactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50059989((1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-phenyl)-he...)

Ki: 1.82E+4nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair

Purchase ChEBI
CHEMBL PC cid PC sid Patents Similars

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Lactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)

Ki: 2.44E+4nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Lactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50295287(2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)ace...)

Ki: 8.78E+4nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair

Purchase ChEBI
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB Patents

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Lactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50027952(5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acet...)

Ki: 3.35E+5nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair

Purchase ChEBI
CHEMBL DrugBank MMDB PC cid PC sid PDB Patents Similars

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Lactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM54705(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)

Ki: 3.83E+5nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair

Purchase ChEBI
CHEMBL DrugBank KEGG PC cid PC sid PDB Similars

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Lactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50022271(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)

Ki: 8.43E+5nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG PC cid PC sid PDB Patents Similars

Acetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
The Chinese Academy Of Sciences

Curated by ChEMBL

BDBM50304324((1R,9R)-1-{[1-(3,5-Dimethoxy-phenyl)-methylidene]-...)

IC50: 0.0200nMAssay Description:Inhibition of Torpedo california AChE by Ellman's methodMore data for this Ligand-Target Pair

Acetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
The Chinese Academy Of Sciences

Curated by ChEMBL

BDBM50304322((1R,9R)-13-Eth-(E)-ylidene-1-{[1-(4-methoxy-phenyl...)

IC50: 0.0246nMAssay Description:Inhibition of Torpedo california AChE by Ellman's methodMore data for this Ligand-Target Pair

Acetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
The Chinese Academy Of Sciences

Curated by ChEMBL

BDBM50304326(4-{[13-Ethylidene-11-methyl-5-oxo-6-aza-tricyclo[7...)

IC50: 0.0412nMAssay Description:Inhibition of Torpedo california AChE by Ellman's methodMore data for this Ligand-Target Pair

Acetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
The Chinese Academy Of Sciences

Curated by ChEMBL

BDBM50304325(1-{[1-(2,4-Dimethoxy-phenyl)-methylidene]-amino}-1...)

IC50: 0.0446nMAssay Description:Inhibition of Torpedo california AChE by Ellman's methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))TBA

BDBM50408487(CHEMBL5281567)

IC50: 0.0600nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330411( N4-(3-acetylphenyl)-N6-(1-acryloylazetidin-3-yl)-...)

IC50: 0.100nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair

Acetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
The Chinese Academy Of Sciences

Curated by ChEMBL

BDBM50304330((1R,9R)-1-[3-(4-Dimethylamino-phenyl)-prop-2-enyli...)

IC50: 0.121nMAssay Description:Inhibition of Torpedo california AChE by Ellman's methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))TBA

BDBM50408486(CHEMBL5268340)

IC50: 0.130nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))TBA

BDBM50497974(CHEMBL3319209)

IC50: 0.180nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330400(N6-(1-acryloylpiperidin-4-yl)-N4-(3-chloro-4-fluor...)

IC50: 0.200nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330401((S)—N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330415(N6-(1-acryloylpiperidin-4-yl)-N4-(3-chloro-4-fluor...)

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Homo sapiens (Human))TBA

BDBM50594973(CHEMBL5169811)

IC50: 0.300nMAssay Description:Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))TBA

BDBM50513787(CHEMBL4445635)

IC50: 0.300nMAssay Description:Inhibition of human PDE10A2 catalytic domain (446 to 789 residues) expressed in Escherichia coli BL21 cells using [3H]-cGMP as substrate after 15 min...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330399(N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro-4-fluoro...)

IC50: 0.300nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330413(N6-(1-acryloylpiperidin-4-yl)-N4-(3-bromophenyl)-7...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50459162(CHEMBL4218772)

IC50: 0.320nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))TBA

BDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)

IC50: 0.370nMAssay Description:Inhibition of human PDE10A2 catalytic domain (446 to 789 residues) expressed in Escherichia coli BL21 cells using [3H]-cGMP as substrate after 15 min...More data for this Ligand-Target Pair

Purchase DrugBank MMDB PC cid PC sid PDB Similars

Details Article PubMed MMDB
PDB

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50459175(CHEMBL4204687)

IC50: 0.390nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))TBA

BDBM50398017(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)

IC50: 0.390nMAssay Description:Inhibition of P-glycoprotein expressed in MDCK-MDR1 cells by calcein AM assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330402((S)—N6-(1-acryloylpiperidin-4-yl)-N4-(3-chlor...)

IC50: 0.400nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL

BDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)

IC50: 0.400nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details PubMed DrugBank
PDB

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330417(6-(1-acryloylazetidin-3-yl)thio-N-(3-chloro-4-fluo...)

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
National-Local Joint Engineering Laboratory Of Druggability And New Drugs Evaluation

Curated by ChEMBL

BDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)

IC50: 0.400nMAssay Description:Inhibition of PDE4D2 (unknown origin)More data for this Ligand-Target Pair

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))TBA

BDBM50513788(CHEMBL4558162)

IC50: 0.440nMAssay Description:Inhibition of human PDE10A2 catalytic domain (446 to 789 residues) expressed in Escherichia coli BL21 cells using [3H]-cGMP as substrate after 15 min...More data for this Ligand-Target Pair

PC cid PC sid PDB

Details Article PubMed PDB

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL

BDBM50510261(CHEMBL4590082)

IC50: 0.5nMAssay Description:Inhibition of JAK2 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))TBA

BDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)

IC50: 0.5nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50459172(CHEMBL4217826)

IC50: 0.520nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM317140(US9617269, Compound WYQ-90-D)

IC50: 0.600nMAssay Description:Inhibition activities of all the N-substituted pyrazolo [3,4-d] pyrimidine ketone compounds according to the present invention to the phosphodiestera...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Epidermal growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent

BDBM330406(1-(4-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylami...)

IC50: 0.600nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50034641(CHEMBL3360415)

IC50: 0.600nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair